Folate being an important vitamin of B Complex group in our diet plays an important role not
only in the synthesis of DNA but also in the maintenance of methylation reactions in the …

This paper reviews the chemistry, metabolism, and molecular biology of folic acid, with a
particular emphasis on how it is, or may be, involved in many disease processes. Folic acid …

Referee: S Hill, McMaster University, Hamilton, Canada Folic acid is an essential nutrient
from the B complex group of vitamins. Folate, as a cofactor, is involved in numerous …

Folate functions as a coenzyme to transfer one‐carbon units that are necessary for
deoxythymidylate synthesis, purine synthesis, and various methylation reactions. Ingested …

Folates have a pterine core structure and high metabolic activity due to their ability to accept
electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential …

Folates are important cofactors in the transfer and utilization of one-carbon-groups and play
a key role in the remethylation of methionine thus providing essential methyl groups for …

In mammalian and plant cells the folates play a key role in the methylation cycle and in the
DNA biosynthesis cycle (in the de novo biosynthesis of purines and pyrimidines). Deficiency …

These are exciting times for those interested in the interaction of genetic and environmental
factors in disease. Foic acid has recently gained a great deal of prominence as a biołogically …

As described in the previous chapter, natural folate compounds exist in tissues as
polyglutamates. These serve to keep the folates within the cell since only the …

Folate-mediated 1-carbon metabolism is a network of interconnected metabolic pathways
necessary for the synthesis of purine nucleotides, thymidylate and the remethylation of …