The type I interferon (IFN) response protects cells from viral infection by inducing hundreds
of interferon-stimulated genes (ISGs), some of which encode direct antiviral effectors …

The type I interferon response protects cells against invading viral pathogens. The cellular
factors that mediate this defence are the products of interferon-stimulated genes (ISGs) …

Abstract Cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA during viral infection and
catalyzes synthesis of the dinucleotide cGAMP, which activates the adaptor STING to initiate …

Cellular sensing of virus-derived nucleic acids is essential for early defenses against virus
infections. In recent years, the discovery of DNA sensing proteins, including cyclic GMP …

Innate immune activation by macrophages is an essential part of host defence against
infection. Cytosolic recognition of microbial DNA in macrophages leads to induction of …

Innate immune recognition of foreign nucleic acids induces protective interferon responses.
Detection of cytosolic DNA triggers downstream immune signaling through activation of …

The past decade has provided critical information about the cytoplasmic innate immune
sensing pathway of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes …

The human interferon-inducible protein IFI16 is an important antiviral factor that binds
nuclear viral DNA and promotes antiviral responses. Here, we define IFI16 dynamics in …

Rapid and robust induction of type I IFN (IFN-I) is a critical event in host antiviral innate
immune response. It has been well demonstrated that cyclic GMP-AMP (cGAMP) synthase …

Nucleic acids from bacteria or viruses induce potent immune responses in infected cells,,–.
The detection of pathogen-derived nucleic acids is a central strategy by which the host …