Functional angiotensin II receptors have been documented in cardiac fibroblasts as well as
an intracardiac aldosterone system that responds to short-and long-term physiological …

The renin-angiotensin-aldosterone system has emerged as a potential candidate for the
accumulation of collagen in cardiac fibroblasts. The traditional renin-angiotensin …

The possible contributions of the angiotensin receptor subtypes 1 (AT1) and 2 (AT2) to
angiotensin II (Ang II)-induced changes in collagen secretion and production were studied …

The possible contributions of the angiotensin receptor subtypes 1 (AT1) and 2 (AT2) to
angiotensin II-induced changes in collagen secretion and production were studied using the …

Cardiac fibrosis can be accompanied initially by diastolic and ultimately by systolic
ventricular dysfunction. Clinical and experimental evidence suggests a clear association …

In chronic heart failure, various regulatory systems including the Frank-Starling mechanism,
the neuro-hormonal response, cardiac growth and peripheral oxygen delivery may be …

Background Left ventricular hypertrophy is an adaptive process to increased loading of the
left ventricle. This condition becomes pathologic with impaired myocardial function if the …

P. Lijnen and V. Petrov. Induction of Cardiac Fibrosis by Aldosterone. Journal of Molecular
and Cellular Cardiology (2000) 32, 865–879. An intracardiac aldosterone system which …

The interstitial space of the myocardium is composed of nonmyocyte cells and a highly
organized collagen network which serves to maintain the architecture and mechanical …

Cardiac fibroblasts, an abundant cell of the left ventricle (LV), proliferate and synthesize
collagen in the heart after acute injury and during pressure overload hypertrophy. From …