1. The hypothalamo-pituitary-adrenal axis (HPA) 574 1.1. Control of glucocorticoid levels
during stress 577 1.2. The diurnal rhythm of HPA activity 579 2. Roles of corticotropin …

Corticotropin-releasing hormone (CRH), a 41-amino-acid peptide, is one of the major
secretagogues of pituitary ACTH release.'It is synthesized by neurons located mainly in the …

A functional ultrastructural assay was used to determine the response of corticotropin
releasing hormone (CRH) neurosecretory cells to short-term stress. Depletion of …

The physiological regulation of ACTH secretion is largely dependent on the interactive
effects of CRH and vasopressin (VP) in the pituitary corticotroph. The importance of the …

I. A Brief History of Corticotropin-Releasing Hormone (CRH) and Vasopressin as Mediators
of Pituitary-Adrenal Activation in Humans HARRIS'1948 hypothesis (1) that anterior pituitary …

Descriptions of the central distribution of corticotropin‐releasing factor (CRF) have been
taken as generally supporting the proposition that this neuropeptide is involved in the …

More than 40 years ago Harris (1948) proposed that pituitary adrenocorticotrophic hormone
(ACTH) secretion might be regulated by humoral factors released from the hypothalamus …

Publisher Summary This chapter outlines current views about the organization of neural
circuitry underlying the integration of stress responses, with special emphasis on the …

The release of corticotropin-releasing factor (CRF) is controlled by several factors including
stress, circadian rhythm, and feedback mechanisms. It is generally accepted that the …

The regulatory actions of CRF during the neuroendocrine response to stress are mediated
by specific receptors within the nervous system and the anterior pituitary gland …