[HTML][HTML] Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy

D Liu, L Chen, H Zhao, ND Vaziri, SC Ma… - Biomedicine & …, 2019 - Elsevier
The Wnt/β-catenin signaling pathway is an evolutionarily conserved developmental
signaling event that plays a critical role in regulating tissue development and maintaining …

Activating Wnt/β-catenin signaling pathway for disease therapy: Challenges and opportunities

P Huang, R Yan, X Zhang, L Wang, X Ke… - Pharmacology & …, 2019 - Elsevier
Wnt/β-catenin signaling pathway is essential for embryo development and adult tissue
homeostasis and regeneration, abnormal regulation of the pathway is tightly associated with …

[HTML][HTML] Small molecule Wnt pathway modulators from natural sources: history, state of the art and perspectives

A Blagodatski, A Klimenko, L Jia, VL Katanaev - Cells, 2020 - mdpi.com
The Wnt signaling is one of the major pathways known to regulate embryonic development,
tissue renewal and regeneration in multicellular organisms. Dysregulations of the pathway …

[HTML][HTML] Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

J Liu, Q Xiao, J Xiao, C Niu, Y Li, X Zhang… - Signal transduction and …, 2022 - nature.com
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

[HTML][HTML] Targeting β-catenin signaling by natural products for cancer prevention and therapy

WK Yu, ZY Xu, L Yuan, S Mo, B Xu… - Frontiers in …, 2020 - frontiersin.org
The mutations and deregulation of Wnt signaling pathway occur commonly in human cancer
and cause the aberrant activation of β-catenin and β-catenin-dependent transcription, thus …

The Wnt/β-catenin signaling pathway as a target in drug discovery

F Takahashi-Yanaga, T Sasaguri - Journal of pharmacological …, 2007 - jstage.jst.go.jp
The cell signaling cascades provoked by Wnt proteins (the Wnt signaling pathways), which
are well conserved through evolution, play crucial roles to maintain homeostasis of a variety …

[HTML][HTML] Nature-derived compounds modulating Wnt/β-catenin pathway: a preventive and therapeutic opportunity in neoplastic diseases

G Sferrazza, M Corti, G Brusotti, P Pierimarchi… - … Pharmaceutica Sinica B, 2020 - Elsevier
The Wnt/β-catenin signaling is a conserved pathway that has a crucial role in embryonic and
adult life. Dysregulation of the Wnt/β-catenin pathway has been associated with diseases …

Natural compounds with Wnt signal modulating activity

RG Fuentes, MA Arai, M Ishibashi - Natural Product Reports, 2015 - pubs.rsc.org
Covering: up to 2015 The Wnt signalling pathway is essential in many biological processes.
The Wnt signal is associated with several diseases, particularly cancer and …

[HTML][HTML] Therapeutic potential of naturally occurring small molecules to target the wnt/β-catenin signaling pathway in colorectal cancer

LFS Oliveira, D Predes, HL Borges, JG Abreu - Cancers, 2022 - mdpi.com
Simple Summary Colorectal cancer (CRC) is an emerging public health problem and the
second leading cause of death worldwide, with a significant socioeconomic impact in …

Wnt/β-catenin signaling inhibitors

X Zhang, N Dong, X Hu - Current Topics in Medicinal …, 2023 - ingentaconnect.com
The Wnt/β-catenin signaling pathway plays a crucial role in the development, tissue
homeostasis, angiogenesis, and carcinogenesis of cancer. Mutations and excessive …