Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation

RR Resende, A Adhikari - Cell Communication and Signaling, 2009 - Springer
Acetylcholine (ACh) has been shown to modulate neuronal differentiation during early
development. Both muscarinic and nicotinic acetylcholine receptors (AChRs) regulate a …

Acetylcholine as a possible signaling molecule in embryonic stem cells: studies on survival, proliferation and death

D Landgraf, M Barth, PG Layer, LE Sperling - Chemico-biological …, 2010 - Elsevier
Acetylcholine (ACh) has always been regarded as a classical neurotransmitter that binds to
nicotinic or muscarinic receptors and mediates signal transmission. The traditional view, that …

Mechanism of acetylcholine-induced calcium signaling during neuronal differentiation of P19 embryonal carcinoma cells in vitro

RR Resende, KN Gomes, A Adhikari, LRG Britto… - Cell calcium, 2008 - Elsevier
Muscarinic (mAChRs) and nicotinic acetylcholine receptors (nAChRs) are involved in
various physiological processes, including neuronal development. We provide evidence for …

Acetylcholine stimulates cortical precursor cell proliferation in vitro via muscarinic receptor activation and MAP kinase phosphorylation

W Ma, D Maric, B Li, Q Hu, JD Andreadis… - European Journal of …, 2000 - Wiley Online Library
Increasing evidence has shown that some neurotransmitters act as growth‐regulatory
signals during brain development. Here we report a role for the classical neurotransmitter …

The cholinergic 'pitfall': acetylcholine, a universal cell molecule in biological systems, including humans

I Wessler, CJ Kirkpatrick… - Clinical and Experimental …, 1999 - Wiley Online Library
1. Acetylcholine (ACh) represents one of the most exemplary neurotransmitters. In addition
to its presence in neuronal tissue, there is increasing experimental evidence that ACh is …

Developmental aspects of the cholinergic system

Y Abreu-Villaça, CC Filgueiras, AC Manhães - Behavioural brain research, 2011 - Elsevier
Beyond its importance in sustaining or modulating different aspects of the activity of the
central nervous system (CNS), the cholinergic system plays important roles during …

Role of acetylcholine receptors in proliferation and differentiation of P19 embryonal carcinoma cells

RR Resende, AS Alves, LRG Britto, H Ulrich - Experimental cell research, 2008 - Elsevier
Coordinated proliferation and differentiation of progenitor cells is the base for production of
appropriate numbers of neurons and glia during neuronal development in order to establish …

Basic and clinical aspects of non-neuronal acetylcholine: overview of non-neuronal cholinergic systems and their biological

SK Kawashima, T Fujii - Journal of pharmacological sciences, 2008 - Elsevier
Acetylcholine (ACh) is a phylogenetically ancient molecule involved in cell-to-cell signaling
in almost all life-forms on earth. Cholinergic components, including ACh, choline …

A review of the cholinergic system and therapeutic approaches to treat brain disorders

D Bertrand, TL Wallace - Behavioral Pharmacology of the Cholinergic …, 2020 - Springer
Since its identification over a hundred years ago, the neurotransmitter acetylcholine (ACh)
has proven to play an essential role in supporting many diverse functions. Some well …

Acetylcholine beyond neurons: the non‐neuronal cholinergic system in humans

I Wessler, CJ Kirkpatrick - British journal of pharmacology, 2008 - Wiley Online Library
Animal life is controlled by neurons and in this setting cholinergic neurons play an important
role. Cholinergic neurons release ACh, which via nicotinic and muscarinic receptors (n‐and …