The analysis of animal models of neurological disease has been instrumental in furthering
our understanding of neurodevelopment and brain diseases. However, animal models are …

The human brain is arguably the most complex structure among living organisms. However,
the specific mechanisms leading to this complexity remain incompletely understood …

Understanding the development and dysfunction of the human brain is a major goal of
neurobiology. Much of our current understanding of human brain development has been …

Neurodevelopmental disorders (NDs) are impairments that affect the development and
growth of the brain and the central nervous system during embryonic and early postnatal life …

Among the disciplines of medicine, the study of neurological disorders is particularly
challenging. The fundamental inaccessibility of the human neural types affected by disease …

Embryonic or induced pluripotent stem cells, available in mouse and human, have emerged
as powerful tools to address complex questions in neurobiology. This review focuses on …

We currently have a poor understanding of the pathogenesis of neurodevelopmental
disorders, owing to the fact that postmortem and imaging studies can only measure the …

In the past few years, cellular programming, whereby virtually all human cell types, including
those deep within the brain or internal organs, can potentially be produced and propagated …

Induced pluripotent stem cells and embryonic stem cells have revolutionized cellular
neuroscience, providing the opportunity to model neurological diseases and test potential …

Seven years have passed since the initial report of the generation of induced pluripotent
stem cells (iPSCs) from adult human somatic cells, and in the intervening time the field of …