Baicalin promotes the activation of brown and white adipose tissue through AMPK/PGC1α pathway

Y Zhang, Z Zhang, Y Zhang, L Wu, L Gao, R Yao… - European Journal of …, 2022 - Elsevier
Obesity occurs when energy intake overtops energy expenditure. Promoting activation of
brown adipose tissue (BAT) and white adipose tissue (WAT) has been proven a promising …

The mechanisms of baicalin ameliorate obesity and hyperlipidemia through a network pharmacology approach

ZY Wang, ZM Jiang, PT Xiao, YQ Jiang, WJ Liu… - European Journal of …, 2020 - Elsevier
Obesity is one of the main causes of human cardiovascular and cerebrovascular diseases.
Baicalin, a bioactive flavonoid isolated from the herbal medicine Scutellaria baicalensis …

Baicalin against obesity and insulin resistance through activation of AKT/AS160/GLUT4 pathway

P Fang, M Yu, L Zhang, D Wan, M Shi, Y Zhu… - Molecular and cellular …, 2017 - Elsevier
Obesity may cause several metabolic complications, including insulin resistance and type 2
diabetes mellitus. Despite great advances in medicine, people still keep exploring novel and …

Baicalin attenuates diet-induced obesity partially through promoting thermogenesis in adipose tissue

H Li, S Tang - Obesity research & clinical practice, 2021 - Elsevier
Background Adipose tissues have essential roles on energy homeostasis and the
development of metabolic syndrome and obesity, they have become critical targets for …

Baicalin attenuates high fat diet-induced insulin resistance and ectopic fat storage in skeletal muscle, through modulating the protein kinase B/Glycogen synthase …

XI You-Li, LI Hong-Xia, C Chen, LIU Ya-Qun… - Chinese Journal of …, 2016 - Elsevier
Insulin resistance is the pathophysiological basis of many diseases. Overcoming early
insulin resistance highly significant in prevention diabetes, non-alcoholic fatty liver, and …

Antiobesity effect of baicalin involves the modulations of proadipogenic and antiadipogenic regulators of the adipogenesis pathway

H Lee, R Kang, Y Hahn, Y Yang, SS Kim… - Phytotherapy …, 2009 - Wiley Online Library
In this study, the antiobesity effects of baicalin, 5, 6‐dihydroxyflavone‐7‐glucuronic acid,
were characterized using an in vitro system of adipogenesis, ie fat cell formation. Baicalin …

Baicalin and its aglycone: a novel approach for treatment of metabolic disorders

P Fang, M Yu, M Shi, P Bo, X Gu, Z Zhang - Pharmacological Reports, 2020 - Springer
Background The current strategies for prevention and treatment of insulin resistance and
type 2 diabetes are not fully effective and frequently accompanied by many negative effects …

Baicalin and its metabolites suppresses gluconeogenesis through activation of AMPK or AKT in insulin resistant HepG-2 cells

T Wang, H Jiang, S Cao, Q Chen, M Cui, Z Wang… - European Journal of …, 2017 - Elsevier
Scutellaria baicalensis Georgi (S. baicalensis), as a traditional Chinese herbal medicine, is
an important component of several famous Chinese medicinal formulas for treating patients …

[HTML][HTML] Baicalin attenuates high fat diet-induced obesity and liver dysfunction: dose-response and potential role of CaMKKβ/AMPK/ACC pathway

Y Xi, M Wu, H Li, S Dong, E Luo, M Gu… - Cellular Physiology and …, 2015 - karger.com
Background/Aims: Obesity-associated fatty liver disease affects millions of individuals. This
study aimed to evaluate the therapeutic effects of baicalin to treat obesity and fatty liver in …

Baicalin protects against insulin resistance and metabolic dysfunction through activation of GALR2/GLUT4 signaling

M Yu, S Han, M Wang, L Han, Y Huang, P Bo, P Fang… - Phytomedicine, 2022 - Elsevier
Background Type 2 diabetes mellitus is a complex metabolic disorder associated with
obesity, glucose intolerance and insulin resistance. Activation of GALR2 has been proposed …