Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …

This review covers literature between 2003–2021 The development and application of
genome mining tools has given rise to ever-growing genetic and chemical databases and …

Genetically encoded small molecules (secondary metabolites) play eminent roles in
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …

The advent of the genomic era has opened up enormous possibilities for the discovery of
new natural products. Also known as specialized metabolites, these compounds produced …

Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …

Genome mining has become a key technology to exploit natural product diversity. Although
initially performed on a single-genome basis, the process is now being scaled up to mine …

New drugs from silent gene clusters: Analysis of genome sequence data has identified
numerous “cryptic” gene clusters encoding novel natural product biosynthetic assembly …

The pairing of analytical chemistry with genomic techniques represents a new wave in
natural product chemistry. With an increase in the availability of sequencing and assembly of …

All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

Recent genome sequencing efforts have led to the rapid accumulation of uncharacterized or
“orphaned” secondary metabolic biosynthesis gene clusters (BGCs) in public databases …