Human African trypanosomiasis (HAT) is a parasitic disease caused by the protozoan
parasites T. b. rhodesiense and T. b. gambiense. The disease is currently endemic in 36 sub …

Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the
protozoan parasites Trypanosoma brucei (Tb) gambiense or Tb rhodesiense and is …

Human African trypanosomiasis (HAT) is a parasitic disease caused by the protozoan
parasites Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense. Following …

Melarsoprol, a water-insoluble drug, is mainly used in the treatment of trypanosomiasis and
has demonstrated an in vitro activity on myeloid and lymphoid leukemia derived cell lines. It …

Human African trypanosomiasis (HAT), or sleeping sickness, is a major threat to human
health throughout sub-Saharan Africa. Almost always fatal if untreated or inadequately …

The aim of this work was to develop and compare two aqueous formulations of melarsoprol
(nanosuspensions and cyclodextrin-inclusion complexes). The arsenic concentrations in the …

In this study we prepared an inclusion complex between an iodide analogue of
metronidazole (MTZ-I) and cyclodextrin (CD) to develop a safer and more effective method …

The present study compares two methods of preparation of microparticles of melarsoprol for
the treatment of the human trypanosomiasis. Melarsoprol is poorly soluble in water and in …

The current chemotherapy for Chagas disease is still based on benznidazole, which has low
solubility, but complexation with cyclodextrins provides a way of increasing the solubility …

The aim of this study is to improve the efficacy of diminazene aceturate via complex
formation with sodium oleate. The complex was subjected to various in vitroand in vivotests …