Methods: We applied electrophysiology, myography, mass spectrometry and in silico
docking to determine effects and their underlying molecular mechanisms of tea and its …

Many commonly consumed plants are used as folk medicines, often with unclear molecular
mechanisms. Recent studies uncovered the ubiquitous and influential KCNQ family of …

The evergreen plant rosemary (Salvia rosmarinus) has been employed medicinally for
centuries as a memory aid, analgesic, spasmolytic, vasorelaxant and antihypertensive, with …

The slowly activating delayed rectifier K+ channels (IKs) are one of the main
pharmacological targets for development of drugs against cardiovascular diseases. Cardiac …

KCNQ4-encoded voltage-dependent potassium (Kv7. 4) channels are important regulators
of vascular tone that are severely compromised in models of hypertension. However, there is …

Botanical folk medicines have been used throughout human history to treat common
disorders such as hypertension, often with unknown underlying mechanisms. Here, we …

Indigenous peoples of the Americas are proficient in botanical medicine. KCNQ family
voltage-gated potassium (Kv) channels are sensitive to a variety of ligands, including plant …

Background—Voltage-gated potassium (K+) channels encoded by KCNQ genes (Kv7
channels) have been identified in various rodent and human blood vessels as key …

Kv7 channels (Kv7. 1–7.5) are voltage-gated K+ channels that can be modulated by five β-
subunits (KCNE1–5). Kv7. 1-KCNE1 channels produce the slow-delayed rectifying K+ …

Voltage-gated potassium (Kv) channels formed by Kv7 (KCNQ) α-subunits are recognized
as crucial for vascular smooth muscle function, in addition to their established roles in the …