Toward theragnostics
F Pene, E Courtine, A Cariou, JP Mira - Critical care medicine, 2009 - journals.lww.com
Theragnostics is a treatment strategy that combines therapeutics with diagnostics. It
associates both a diagnostic test that identifies patients most likely to be helped or harmed …
associates both a diagnostic test that identifies patients most likely to be helped or harmed …
[HTML][HTML] Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness
All of medicine aspires to be precise, where a greater understanding of individual data will
lead to personalized treatment and improved outcomes. Prompted by specific examples in …
lead to personalized treatment and improved outcomes. Prompted by specific examples in …
[PDF][PDF] Biomarkers and precision medicine: state of the art
A Sarma, CS Calfee, LB Ware - Critical care clinics, 2020 - Elsevier
Advances in molecular and computational methods have opened new biomarker-based
approaches to precision medicine in critically ill patients, but several challenges remain …
approaches to precision medicine in critically ill patients, but several challenges remain …
[HTML][HTML] Intensive care medicine in 2050: precision medicine
HR Wong - Intensive care medicine, 2017 - Springer
By 2050, intensive care medicine will evolve from reliance on treatment protocols,
guidelines, consensus definitions, and organ support to regularly applying the principles of …
guidelines, consensus definitions, and organ support to regularly applying the principles of …
[HTML][HTML] The coming era of precision medicine for intensive care
JL Vincent - Critical Care, 2017 - Springer
Recent advances in technology and better understanding of mechanisms underlying
disease are beginning to enable us to better characterize critically ill patients. Instead of …
disease are beginning to enable us to better characterize critically ill patients. Instead of …
Ten reasons why we should NOT use severity scores as entry criteria for clinical trials or in our treatment decisions
JL Vincent, SM Opal, JC Marshall - Critical care medicine, 2010 - journals.lww.com
Objective: Severity scores such as Acute Physiology and Chronic Health Evaluation II have
been advocated as entry criteria for clinical trials and in clinical decision-making. We present …
been advocated as entry criteria for clinical trials and in clinical decision-making. We present …
[HTML][HTML] Personalized medicine for ARDS: the 2035 research agenda
JR Beitler, EC Goligher, M Schmidt, PM Spieth… - Intensive care …, 2016 - Springer
In the last 20 years, survival among patients with acute respiratory distress syndrome
(ARDS) has increased substantially with advances in lung-protective ventilation and …
(ARDS) has increased substantially with advances in lung-protective ventilation and …
Critical care, critical data
CV Cosgriff, LA Celi, DJ Stone - Biomedical engineering and …, 2019 - journals.sagepub.com
As big data, machine learning, and artificial intelligence continue to penetrate into and
transform many facets of our lives, we are witnessing the emergence of these powerful …
transform many facets of our lives, we are witnessing the emergence of these powerful …
In silico design of clinical trials: a method coming of age
G Clermont, J Bartels, R Kumar… - Critical care …, 2004 - journals.lww.com
Objective: To determine the feasibility and potential usefulness of mathematical models in
evaluating immunomodulatory strategies in clinical trials of severe sepsis. Design …
evaluating immunomodulatory strategies in clinical trials of severe sepsis. Design …
Narrowing the 17-year research to practice gap
CL Munro, RH Savel - American Journal of Critical Care, 2016 - AACN
D eveloping evidence to improve clinical practice and disseminating it to be used by
clinicians to improve outcomes for individual patients is important. How long does it take to …
clinicians to improve outcomes for individual patients is important. How long does it take to …