Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

Y Chen, M Lemire, S Choufani, DT Butcher… - Epigenetics, 2013 - Taylor & Francis
DNA methylation, an important type of epigenetic modification in humans, participates in
crucial cellular processes, such as embryonic development, X-inactivation, genomic …

Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array

EM Price, AM Cotton, LL Lam, P Farré, E Emberly… - Epigenetics & …, 2013 - Springer
Background Measurement of genome-wide DNA methylation (DNAm) has become an
important avenue for investigating potential physiologically-relevant epigenetic changes …

Impact of SNPs on methylation readouts by Illumina Infinium HumanMethylation450 BeadChip Array: implications for comparative population studies

P Daca-Roszak, A Pfeifer, J Żebracka-Gala, D Rusinek… - BMC genomics, 2015 - Springer
Abstract Background Infinium HumanMethylation 450 BeadChip Arrays by Illumina (Illumina
HM450K) are among the most popular CpG microarray platforms widely used in biological …

A data-driven approach to preprocessing Illumina 450K methylation array data

R Pidsley, CC Y Wong, M Volta, K Lunnon, J Mill… - BMC genomics, 2013 - Springer
Background As the most stable and experimentally accessible epigenetic mark, DNA
methylation is of great interest to the research community. The landscape of DNA …

A Comparison of the Whole Genome Approach of MeDIP-Seq to the Targeted Approach of the Infinium HumanMethylation450 BeadChip® for Methylome Profiling

C Clark, P Palta, CJ Joyce, C Scott, E Grundberg… - PloS one, 2012 - journals.plos.org
DNA methylation is one of the most studied epigenetic marks in the human genome, with the
result that the desire to map the human methylome has driven the development of several …

[HTML][HTML] Identification of polymorphic and off-target probe binding sites on the Illumina Infinium MethylationEPIC BeadChip

DL McCartney, RM Walker, SW Morris, AM McIntosh… - Genomics data, 2016 - Elsevier
Genome-wide analysis of DNA methylation has now become a relatively inexpensive
technique thanks to array-based methylation profiling technologies. The recently developed …

DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns

K Lokk, V Modhukur, B Rajashekar, K Märtens, R Mägi… - Genome biology, 2014 - Springer
Background DNA epigenetic modifications, such as methylation, are important regulators of
tissue differentiation, contributing to processes of both development and cancer. Profiling the …

Genome-Wide Dna Methylation Profiling Using Infinium® Assay

M Bibikova, J Le, B Barnes, S Saedinia-Melnyk… - …, 2009 - Taylor & Francis
Aims: Bisulfite sequence analysis of individual CpG sites within genomic DNA is a powerful
approach for methylation analysis in the genome. The major limitation of bisulfite-based …

A systematic study of normalization methods for Infinium 450K methylation data using whole-genome bisulfite sequencing data

T Wang, W Guan, J Lin, N Boutaoui, G Canino, J Luo… - Epigenetics, 2015 - Taylor & Francis
DNA methylation plays an important role in disease etiology. The Illumina Infinium
HumanMethylation450 (450K) BeadChip is a widely used platform in large-scale …

Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling

R Pidsley, E Zotenko, TJ Peters, MG Lawrence… - Genome biology, 2016 - Springer
Background In recent years the Illumina HumanMethylation450 (HM450) BeadChip has
provided a user-friendly platform to profile DNA methylation in human samples. However …