[HTML][HTML] Amplification of telomerase (hTERT) gene is a poor prognostic marker in non-small-cell lung cancer

CQ Zhu, JC Cutz, N Liu, D Lau, FA Shepherd… - British journal of …, 2006 - nature.com
Telomerase reactivation is a hallmark of human carcinogenesis. Increased telomerase
activity may result from gene amplification and/or overexpression. This study evaluates the …

Increased telomerase activity and elevated hTERT mRNA expression during multistage carcinogenesis of squamous cell carcinoma of the lung

K Shibuya, T Fujisawa, H Hoshino, M Baba, Y Saitoh… - Cancer, 2001 - Wiley Online Library
BACKGROUND Telomerase activation is believed to be play a critical role in the
immortalization of cells and carcinogenesis. Telomerase activity is undetectable in normal …

hTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer

L Wang, JC Soria, BL Kemp, DD Liu, L Mao… - Clinical cancer …, 2002 - AACR
Activation of telomerase plays a critical role in unlimitedproliferation and immortalization of
cells. The purpose of this study was to evaluate the significance of human telomerase …

Clinicopathologic significance of telomerase activity and hTERT mRNA expression in non-small cell lung cancer

H Hara, K Yamashita, J Shinada, H Yoshimura… - Lung cancer, 2001 - Elsevier
Telomerase has been reported to be a novel diagnostic marker for malignant diseases and
has been recently proven to be composed of three main components, hTR (human …

The diagnostic and prognostic relevance of human telomerase reverse transcriptase mRNA expression detected in situ in patients with nonsmall cell lung carcinoma

Y Fujita, T Fujikane, S Fujiuchi… - … Journal of the …, 2003 - Wiley Online Library
BACKGROUND The objectives of this study were to evaluate the diagnostic and prognostic
relevance of human telomerase reverse transcriptase (hTERT) detected in situ in patients …

[HTML][HTML] Differential expression of telomerase reverse transcriptase (hTERT) in lung tumours

S Lantuejoul, JC Soria, D Moro-Sibilot, L Morat… - British journal of …, 2004 - nature.com
Human telomerase reverse transcriptase is a ribonucleoprotein that synthesises telomeric
sequences, which decrease at each cell division. In cancer cells, its activity is linked to …

Loss of telomerase activity may be a potential favorable prognostic marker in lung carcinomas

TC Wu, P Lin, CP Hsu, YJ Huang, CY Chen… - Lung cancer, 2003 - Elsevier
Many cancer and immortal cells exhibit telomerase activity that stabilizes telomere lengths,
possibly contributing to cell immortality and carcinogenesis. The aim of this study was to …

Expression of human telomerase subunit genes in primary lung cancer and its clinical significance

M Arinaga, S Shimizu, K Gotoh, N Haruki… - The Annals of thoracic …, 2000 - Elsevier
Background. Three major components of human telomerase, RNA component (hTERC),
telomerase-associated protein (TEP1), and catalytic subunit (hTERT) have been cloned …

Concordant expression of the telomerase-associated genes in non-small cell lung cancer

CP Hsu, J Miaw, JY Hsia, SE Shai, CY Chen - European Journal of Surgical …, 2003 - Elsevier
Aims: h-TERT is the keystone gene in controlling telomerase expression under the
modulation of many associated genes. Our study was designed to observe the concordant …

[HTML][HTML] Prediction of survival in stage I lung carcinoma patients by telomerase function evaluation

A Marchetti, C Pellegrini, F Buttitta, M Falleni… - Laboratory …, 2002 - Elsevier
Telomerase activity and telomerase reverse transcriptase (hTERT) expression are elevated
in human malignancies. We have investigated telomerase activity measured by the …