Non-invasive evaluation of response to obeticholic acid in patients with NASH: Results from the REGENERATE study

ME Rinella, JF Dufour, QM Anstee, Z Goodman… - Journal of …, 2022 - Elsevier
Background & Aims Non-alcoholic steatohepatitis (NASH) is a chronic, progressive fibrotic
liver disease that can lead to cirrhosis. While liver biopsy is considered the reference …

Relationship between three commonly used non‐invasive fibrosis biomarkers and improvement in fibrosis stage in patients with non‐alcoholic steatohepatitis

N Chalasani, MF Abdelmalek, R Loomba… - Liver …, 2019 - Wiley Online Library
Abstract Background & Aims Non‐invasive biomarkers are needed for monitoring changes
in liver histology in patients with non‐alcoholic steatohepatitis (NASH). Obeticholic acid …

[PDF][PDF] qFIBS: an automated technique for quantitative evaluation of fibrosis, inflammation, ballooning, and steatosis in patients with nonalcoholic steatohepatitis

F Liu, GBB Goh, D Tiniakos, A Wee, WQ Leow… - …, 2020 - Wiley Online Library
Background and Aims Nonalcoholic steatohepatitis (NASH) is a common cause of chronic
liver disease. Clinical trials use the NASH Clinical Research Network (CRN) system for …

Noninvasive tests accurately identify advanced fibrosis due to NASH: baseline data from the STELLAR trials

QM Anstee, EJ Lawitz, N Alkhouri, VWS Wong… - Hepatology, 2019 - journals.lww.com
Accurate noninvasive tests (NITs) are needed to replace liver biopsy for identifying
advanced fibrosis caused by nonalcoholic steatohepatitis (NASH). We analyzed screening …

The association of histologic and noninvasive tests with adverse clinical and patient-reported outcomes in patients with advanced fibrosis due to nonalcoholic …

ZM Younossi, QM Anstee, VWS Wong, M Trauner… - Gastroenterology, 2021 - Elsevier
Background & Aim Fibrosis is an independent predictor of death in nonalcoholic
steatohepatitis (NASH). We assessed the associations between histologic and noninvasive …

Current complications and challenges in nonalcoholic steatohepatitis screening and diagnosis

P Golabi, M Sayiner, Y Fazel, A Koenig… - Expert review of …, 2016 - Taylor & Francis
Nonalcoholic steatohepatitis (NASH) can lead to complications such as liver failure, cirrhosis
and hepatocellular carcinoma. The diagnostic gold standard for NASH is liver biopsy; …

MRI-based (MAST) score accurately identifies patients with NASH and significant fibrosis

M Noureddin, E Truong, JA Gornbein, R Saouaf… - Journal of …, 2022 - Elsevier
Background & Aims Among the large population of patients with non-alcoholic fatty liver
disease (NAFLD), identifying those with fibrotic non-alcoholic steatohepatitis (Fibro-NASH) …

[HTML][HTML] Liver fibrosis markers of nonalcoholic steatohepatitis

H Enomoto, Y Bando, H Nakamura… - World Journal of …, 2015 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of chronic liver injury.
NAFLD includes a wide range of clinical conditions from simple steatosis to nonalcoholic …

[PDF][PDF] Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future

A Wieckowska, AJ McCullough, AE Feldstein - Hepatology, 2007 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the
United States, and its prevalence is increasing worldwide. It currently affects approximately …

[PDF][PDF] Improvements in histologic features and diagnosis associated with improvement in fibrosis in nonalcoholic steatohepatitis: results from the nonalcoholic …

EM Brunt, DE Kleiner, LA Wilson, AJ Sanyal… - …, 2019 - Wiley Online Library
Hepatocellular injury and inflammation are believed to be the primary drivers of fibrogenesis
that ultimately lead to cirrhosis in patients with nonalcoholic steatohepatitis (NASH). This …