It is known that, compared with normal cells, cancer cells are characterized by an
intensification of glycolysis and an increase in glucose uptake to ensure high proliferative …

Background. Today, the ability for metabolic reprogramming is considered one of the
distinguishing features of metastatically active tumor cells, a classic example of which is …

One hundred years ago, abnormal metabolism of cancer cell was regarded as one of the
most important pathological features of malignancy. Recently, with the development of …

It is well known that tumor cells rely mainly on aerobic glycolysis for energy production even
in the presence of oxygen, and glycolysis is a known modulator of tumorigenesis and tumor …

Lactic acidosis (3 to 40 mM, pH< 6.9) is a condition found in solid tumors because tumor
cells have a high rate of glucose consumption and lactate production even in the presence …

The occurrence and development of tumor are closely related to abnormal cell metabolism.
Tumor cells intake a large amount of glucose, and even with enough oxygen supply, they …

A metabolic change is one of the tumour hallmarks, which has recently attracted a great
amount of attention. One of the main metabolic characteristics of tumour cells is a high level …

Clinical data demonstrate that high pretreatment lactate content is strongly associated with
poor prognosis, advanced, progressive, and metastatic disease in patients with various …

The high glycolytic rate of most tumor cells has puzzled biochemists for a long time. In the
tumor, glucose is aerobically converted to lactate in the cytoplasm rather than being oxidized …

Purpose Cancer cells depend on glucose metabolism via exclusive glycolysis pathway is
named Aerobic glycolysis or Warburg effect. The aim of this study was investigation of …