Ca2+ regulation of contraction in vertebrate striated muscle is exerted primarily through
effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural …

It is 30 years since Ebashi and colleagues showed that Ca2+ ions directly affect regulation
of the myosin‐actin interaction in muscle through the action of tropomyosin and troponin on …

Contraction of striated muscles is regulated by tropomyosin strands that run continuously
along actin-containing thin filaments. Tropomyosin blocks myosin-binding sites on actin in …

This review deals with the regulatory system of striated muscle. In current parlance, the term
regulatory system refers to those proteins that are located in the so-called thin filaments of …

REGULATION BY TROPONIN-TROPOMYOSIN 537 structural changes cause increased
interaction between actin and myosin, enhanced actomyosin ATPase activity, and …

Contraction in all muscles must be precisely regulated and requisite control systems must be
able to adjust to changes in physiological and myopathic stimuli. In this chapter, we outline …

In striated muscles, contractility is controlled by Ca 2+ binding to the regulatory protein
complex troponin, which is a component of the thin filaments. Troponin is an allosteric …

The role of cooperative interactions between individual structural regulatory units (SUs) of
thin filaments (7 actin monomers: 1 tropomyosin: 1 troponin complex) on steady‐state Ca2+ …

Troponin (Tn), containing three subunits: Ca 2+ binding (TnC), inhibitory (TnI), and
tropomyosin binding (TnT), plays a crucial role in the Ca 2+ regulation of vertebrate striated …

Changes in thin filament structure induced by Ca2+ binding to troponin and subsequent
strong cross-bridge binding regulate additional strong cross-bridge attachment, force …