DNA copy number alterations (CNAs), including amplifications and deletions, can result in
significant changes in gene expression and are closely related to the development and …

Motivation Comprehensive catalogue of genes that drive tumor initiation and progression in
cancer is key to advancing diagnostics, therapeutics and treatment. Given the complexity of …

Motivation: Identifying and prioritizing somatic mutations is an important and challenging
area of cancer research that can provide new insights into gene function as well as new …

Motivation The identification of mutated driver genes and the corresponding pathways is one
of the primary goals in understanding tumorigenesis at the patient level. Integration of multi …

Diverse types of cancer genomics data are being collected widely and rapidly with the aim to
systemically examine the origin and dynamics of different diseases. An important premise is …

This paper concerns a study indicating that the expression levels of genes in signaling
pathways can be modeled using a causal Bayesian network (BN) that is altered in tumorous …

While the tumorigenic effects of specific recurrent mutations in known cancer driver-genes is
well-characterized, not much is known about the functional relevance of the vast majority of …

Simple Summary Numerous factors, such as genomic mutations, chromosomal changes,
transcriptional controls, phosphorylation, and protein–protein interactions, among others …

Cancer is a disease often characterized by the presence of multiple genomic alterations,
which trigger altered transcriptional patterns and gene expression, which in turn sustain the …

Precision medicine for cancer involves identifying and targeting the somatic genome
alterations (SGAs) that drive the development of an individual tumor. Much of current efforts …