Recent developments in next-generation sequencing technologies have brought recognition
of microbial genomes as a rich resource for novel natural product discovery. However …

In the ongoing effort to unlock the chemical potential of marine bacteria, genetic engineering
of biosynthetic gene clusters (BGCs) is increasingly used to awake or improve expression of …

Daptomycin, a cyclic lipopeptide produced by Streptomyces roseosporus, is the active
ingredient of Cubicin (daptomycin-for-injection), a first-in-class antibiotic approved for …

Nonribosomal peptide synthetases (NRPSs) are giant multi-enzymes that carry out
sequencial assembly line couplings of amino acids to generate linear or cyclic peptides …

Recent genome sequencing efforts have led to the rapid accumulation of uncharacterized or
“orphaned” secondary metabolic biosynthesis gene clusters (BGCs) in public databases …

Daptomycin is a lipopeptide antibiotic produced by a nonribosomal peptide synthetase
(NRPS) in Streptomyces roseosporus. The holoenzyme is composed of three subunits …

Secondary metabolites represent a virtually inexhaustible source of natural molecules
exhibiting a high potential as pharmaceuticals or chemical building blocks. To gain broad …

Bacilli are ubiquitous low G+ C environmental Gram-positive bacteria that produce a wide
assortment of specialized small molecules. Although their natural product biosynthetic …

Complex microbial ecosystems contain large reservoirs of unexplored biosynthetic diversity.
Here we provide an experimental framework and data analysis tool to facilitate the targeted …

Covering: up to 2022 Streptomyces are ubiquitous in terrestrial and marine environments,
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …