[HTML][HTML] Unlocking the Mechanistic Potential of Thuja occidentalis for Managing Diabetic Neuropathy and Nephropathy

S Singh, TG Singh - Journal of Traditional and Complementary Medicine, 2024 - Elsevier
Diabetes mellitus and its debilitating microvascular complications, including diabetic
neuropathy and nephropathy, represent a growing global health burden. Despite advances …

Pharmacological evaluation of Thuja occidentalis for the attenuation of nephropathy in streptozotocin-induced diabetes rats

SK Bhargava, TG Singh, A Mannan, S Singh, S Gupta - Obesity Medicine, 2022 - Elsevier
Background In diabetic nephropathy (DN), chronic hyperglycemia causes oxidative stress
and dyslipidemia, resulting in chronic renal damage. To mitigate the effects of …

Biomarkers and signaling pathways of diabetic nephropathy and peripheral neuropathy: Possible therapeutic intervention of rutin and quercetin

TF Roohi, S Mehdi, S Aarfi, KL Krishna, S Pathak… - Diabetology …, 2024 - Springer
Diabetic nephropathy and peripheral neuropathy are the two main complications of chronic
diabetes that contribute to high morbidity and mortality. These conditions are characterized …

A study on the mechanism of milkvetch root in the treatment of diabetic nephropathy based on network pharmacology

C Piao, Q Zhang, D Jin, L Wang, C Tang… - Evidence‐Based …, 2020 - Wiley Online Library
Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus.
Owing to its complicated pathogenesis, no satisfactory treatment strategies for DN are …

[HTML][HTML] Antioxidant and anti-inflammatory activities of Centratherum anthelminticum (L.) Kuntze seed oil in diabetic nephropathy via modulation of Nrf-2/HO-1 and NF …

N Baig, R Sultan, SA Qureshi - BMC Complementary Medicine and …, 2022 - Springer
Background Type 2 diabetes mellitus (T2DM) approximately constitutes 90% of the reported
cases. 30-40% of diabetics eventually develop diabetic nephropathy (DN); accounting for …

Pharmacological evaluation of Thuja occidentalis for the attenuation of neuropathy via AGEs and TNF-α inhibition in diabetic neuropathic rats

SK Bhargava, TG Singh, A Mannan, S Singh… - … Science and Pollution …, 2022 - Springer
When diabetes neuropathy occurs, the oxidative stress caused by chronic hyperglycemia
may result in chronic neuronal damage. To mitigate the effects of hyperglycemia-induced …

Mechanistic role of Syzygium cumini (L.) Skeels in glycation induced diabetic nephropathy via RAGE–NF–κB pathway and extracellular proteins modifications: A …

MM Apte, E Khattar, RS Tupe - Journal of Ethnopharmacology, 2024 - Elsevier
Ethnopharmacology relevance Syzygium cumini (L.) Skeels (SC), an ancient medicinal
plant, is used as a complementary and alternative medicine for treating diabetes mellitus …

[HTML][HTML] Effect of Quamoclit angulata Extract Supplementation on Oxidative Stress and Inflammation on Hyperglycemia-Induced Renal Damage in Type 2 Diabetic …

JE Park, H Lee, H Rho, SM Hong, SY Kim, Y Lim - Antioxidants, 2020 - mdpi.com
Type 2 diabetes mellitus (T2DM) is caused by abnormalities of controlling blood glucose
and insulin homeostasis. Especially, hyperglycemia causes hyper-inflammation through …

Insights into the Therapeutic uses of Plant Derive Phytocompounds on Diabetic Nephropathy

P Mitra, S Jana, S Roy - Current Diabetes Reviews, 2024 - ingentaconnect.com
Diabetic nephropathy (DN) is one of the primary consequences of diabetes mellitus,
affecting many people worldwide and is the main cause of death under the age of sixty …

Effective dose/duration of natural flavonoid quercetin for treatment of diabetic nephropathy: A systematic review and meta-analysis of rodent data

Z Li, H Deng, X Guo, S Yan, C Lu, Z Zhao, X Feng, Q Li… - Phytomedicine, 2022 - Elsevier
Background Given the challenges on diabetic nephropathy (DN) treatment, research has
been carried out progressively focusing on dietary nutrition and natural products as a novel …