Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as …
MF El-Behairy, WH Abd-Allah, MM Khalifa… - Journal of Enzyme …, 2023 - Taylor & Francis
In this research, two novel series of dibenzo [b, f] azepines (14 candidates) were designed
and synthesised based on the rigidification principle and following the reported …
and synthesised based on the rigidification principle and following the reported …
Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in vitro and in vivo
Y Pang, H Lin, C Ou, Y Cao, B An, J Yan, X Li - European journal of …, 2019 - Elsevier
A series of novel structurally-related tubulin polymerization inhibitors based on
benzodiazepine were designed, synthesized, and evaluated for anticancer activity …
benzodiazepine were designed, synthesized, and evaluated for anticancer activity …
New fused pyrimidine derivatives with anticancer activity: synthesis, topoisomerase II inhibition, apoptotic inducing activity and molecular modeling study
MTM Nemr, AM AboulMagd - Bioorganic Chemistry, 2020 - Elsevier
A new series of triazolopyrimidines and thiazolopyrimidine hydrobromides was designed
and prepared as topoisomerase II inhibitors. Screening of all synthesized compounds was …
and prepared as topoisomerase II inhibitors. Screening of all synthesized compounds was …
Synthesis, in vitro, and in silico studies of novel poly‐heterocyclic compounds bearing pyridine and furan moieties as potential anticancer agents
Thirteen novel poly‐heterocyclic compounds containing pyridine and furan moieties were
synthesized and fully characterized by 1 H NMR, 13 C NMR, FTIR, and elemental analysis …
synthesized and fully characterized by 1 H NMR, 13 C NMR, FTIR, and elemental analysis …
Anticancer activity of new compounds using benzimidazole as a scaffold
The design and synthesis of substituted 1-(1-ethy-1H-benzimidazol-2-yl) ethanone (3a-f)
and substituted 1-(2-bromoethyl)-2-(1-hydrazinylidene or ethylidene)-1H-benzimidazole (3g …
and substituted 1-(2-bromoethyl)-2-(1-hydrazinylidene or ethylidene)-1H-benzimidazole (3g …
Development of β-carboline-benzothiazole hybrids via carboxamide formation as cytotoxic agents: DNA intercalative topoisomerase IIα inhibition and apoptosis …
In quest of promising anticancer agents, the pharmacophores of natural (β-carboline) and
synthetic origin (benzothiazole) were adjoined by a carboxamide bridge and three-point …
synthetic origin (benzothiazole) were adjoined by a carboxamide bridge and three-point …
[HTML][HTML] Design and synthesis of benzimidazoles containing substituted oxadiazole, thiadiazole and triazolo-thiadiazines as a source of new anticancer agents
Based on the heterocyclic core of bendamustine, four series (4a–g, 5a–f, 8a–b and 9a–b) of
benzimidazole derivatives were designed and synthesized starting from 4-(1H-benzo [d] …
benzimidazole derivatives were designed and synthesized starting from 4-(1H-benzo [d] …
Synthesis, anticancer evaluation and molecular docking studies of new heterocycles linked to sulfonamide moiety as novel human topoisomerase types I and II …
AH Halawa, WE Elgammal, SM Hassan, AH Hassan… - Bioorganic …, 2020 - Elsevier
A series of heterocyclic compounds with a sulfonamide moiety were synthesized from
reaction of enaminone 4 with active methylene compounds, glycine derivatives, 1, 4 …
reaction of enaminone 4 with active methylene compounds, glycine derivatives, 1, 4 …
Design and synthesis of β-carboline linked aryl sulfonyl piperazine derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability
KL Manasa, S Thatikonda, DK Sigalapalli, A Sagar… - Bioorganic …, 2020 - Elsevier
A series of new β-carboline linked aryl sulfonyl piperazine congeners have been
synthesized by coupling various β-carboline acids with substituted aryl sulfonyl piperazines …
synthesized by coupling various β-carboline acids with substituted aryl sulfonyl piperazines …
Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole-1, 3, 4-oxadiazole derivatives as human topoisomerase types I poison
In this study, some benzimidazole-oxadiazole derivatives were synthesised and tested for
their in vitro anticancer activities on five cancer cell lines, including HeLa, MCF7, A549 …
their in vitro anticancer activities on five cancer cell lines, including HeLa, MCF7, A549 …