Until recently, the study of age-related decline in fertility has focused primarily on the ovary;
depletion of the finite pool of oocytes and increases in meiotic errors leading to oocyte …

BACKGROUND Modern lifestyle has led to an increase in the age at conception. Advanced
age is one of the critical risk factors for female-related infertility. It is well known that maternal …

STUDY QUESTION What changes occur in the endometrium during aging, and do they
impact fertility? SUMMARY ANSWER Both the transcriptome and cellular composition of …

The twenties are typically considered the prime reproductive years for women. However, in
today's modern world, many women are choosing to delay family planning, resulting in an …

STUDY QUESTION Does age affect endometrial gene expression? SUMMARY ANSWER
Using unsupervised artificial intelligence methods, we report for the first time that …

BACKGROUND Rising maternal ages and age-related fertility decline are a global
challenge for modern reproductive medicine. Clinicians and researchers pay specific …

As the mean age of first-time mothers increases in the industrialized world, inquiries into
causes of human reproductive senescence have followed. Rates of ovulatory dysfunction …

The human endometrium is a highly dynamic tissue that is cyclically shed, repaired,
regenerated and remodelled, primarily under the orchestration of oestrogen and …

Uterine aging is an important factor that impacts fertility, reproductive health, and uterus-
related diseases; however, it remains poorly explored. Functionally, these disturbances …

The uterus is an indispensable organ for the development of a new life in eutherian
mammals. The female mammalian reproductive capacity diminishes with age. In this …