Neuronal activity in the brain is thought to be coupled to cerebral arterioles (functional
hyperemia) through Ca2+ signals in astrocytes. Although functional hyperemia occurs …

Dynamic changes in astrocyte free Ca 2+ regulate synaptic signaling and local blood flow.
Although astrocytes are poised to integrate signals from synapses and the vasculature to …

The role of astrocytes in neurovascular coupling (NVC) is unclear. Here, we applied a
multimodality imaging approach to concomitantly measure synchronized neuronal or …

Astrocytes are electrically non-excitable cells that, on a slow time scale of seconds, integrate
synaptic transmission by dynamic increases in cytosolic Ca 2+. A number of groups have …

Active neurons communicate to intracerebral arterioles in part through an elevation of
cytosolic Ca2+ concentration ([Ca2+] i) in astrocytes, leading to the generation of vasoactive …

In the brain, increased neuronal synaptic activity is accompanied by an increase in local
cerebral blood flow that serves to satisfy neuronal metabolic demands. This linkage between …

Elevation of intracellular Ca2+ in astrocytes can influence cerebral microcirculation and
modulate synaptic transmission. Recently, in vivo imaging studies identified delayed …

Basal and activity-dependent cerebral blood flow changes are coordinated by the action of
critical processes, including cerebral autoregulation, endothelial-mediated signaling, and …

Normal brain function requires proper supply of oxygen and glucose in a timely and local
manner. This is achieved through an orchestrated intercellular communication between …

A growing number of studies support an important contribution of astrocytes to
neurovascular coupling, ie, the phenomenon by which variations in neuronal activity trigger …