Abstract Cyclooxygenases (COX), prostaglandin E 2 (PGE 2) and nitric oxide (NO) are
believed to be some of the most important factors related to colon cancer growth and …

In colorectal cancers, the local cytokine network and the levels of nitric oxide (NO) and
reactive oxygen species (ROS) are known to be closely related to cancer progression and …

Objectives Up to now it has been unclear whether stromal/epithelial interaction affects
progression of colon cancer. This study was designed to examine effects of tumour necrosis …

Abstract Cyclooxygenase-2 (COX-2) plays important roles in tumor development. Especially
in the early-stage colorectal tumors, COX-2 expression is often observed in the tumor …

Nonsteroidal anti-inflammatory drugs are known to suppress the occurrence and
progression of malignancies such as colorectal cancers. However, the precise mechanism …

Purpose: Up-regulation of both inducible nitric oxide synthase (iNOS) and cyclooxygenase-2
(COX-2) enzymes has been reported in colorectal cancer. We aimed at evaluating the …

BACKGROUND: Recent studies have shown that the cyclooxygenase (COX) and the
inducible nitric oxide synthase (iNOS) pathways are involved in the development of tumor …

It is well known that tumor-surrounding stromal tissues support tumor development through
secreting soluble factors such as various cytokines, chemokines, and growth factors. It has …

It has been suggested that nitric oxide (NO) derived from chronically inflamed tissues is a
cause of carcinogenesis. We herein demonstrated that administration of an inducible NO …

The use of non‐steroidal anti‐inflammatory drugs has proved of great interest in the
prevention and treatment of colorectal cancer, although their precise mechanisms of action …