Benzodiazepines have been in use for over half a century. While they remain highly
prescribed, their unfavorable side-effect profile and abuse liability motivated a search for …

Benzodiazepines are widely used clinically to treat anxiety and insomnia. They also induce
muscle relaxation, control epileptic seizures, and can produce amnesia. Moreover …

Benzodiazepines such as diazepam are widely prescribed as anxiolytics and sleep aids.
Continued use of benzodiazepines, however, can lead to addiction in vulnerable …

Benzodiazepines exert their effects by binding to multiple subtypes of the GABAA receptor,
the predominant subtypes in the brain being those that contain α1-, α2-, α3-, and α5 …

When benzodiazepines (BZs) supplanted barbiturates as a favored, safer treatment for
anxiety and sleep disorders in the 1960s, the abuse liability and dependence potential of …

Benzodiazepine (BZ) anxiolytics mediate their clinical effects by enhancing the effect of γ-
aminobutyric acid (GABA) at the GABA-A receptor. Classical BZ full agonists such as …

Chronic use of benzodiazepines for the treatment of anxiety has revealed that these drugs
can lead to dependence as indicated by withdrawal symptoms following cessation and …

Over the past several decades, benzodiazepines and the newer non-benzodiazepines have
become the anxiolytic/hypnotics of choice over the more readily abused barbiturates. While …

Inhibitory neurotransmission in the brain is largely mediated by GABA A receptors.
Potentiation of GABA receptor activation through an allosteric benzodiazepine (BZ) site …

GABAA receptors have important physiological functions, as revealed by pharmacological
studies and experiments involving gene-targeted mouse models, and are the target of …