Tumor hypoxia has been associated with cancer progression, angiogenesis, and metastasis
via modifications in the release and cargo composition of extracellular vesicles secreted by …

Hypoxia, a common condition of the tumor microenvironment, is associated with poor patient
prognosis, tumor cell migration, invasion and metastasis. Recent evidence suggests that …

Rapidly expanding solid tumors demand large quantities of nutrients and oxygen. Growing
tumors exploit preexisting vessels and/or develop new vessels (vascularization) to obtain …

Tumour hypoxia is a hallmark of solid tumours and contributes to tumour progression,
metastasis development and therapy resistance. In response to hypoxia, tumour cells …

Intercellular communication is vital to tumor progression. In this issue of Developmental Cell,
Bertolini et al.(2020) describe how small extracellular vesicles released from hypoxic …

Tumor progression involves a series of biologically important steps in which the crosstalk
between cancer cells and the surrounding environment is an important issue. Angiogenesis …

Oxygen (O2) supply is constantly maintained by the vascular network for a proper tissue
oxygenation. Hypoxia is the result of an increased O2 demand and/or decreased supply and …

Hypoxia, or low oxygen tension, is a major regulator of tumor development and
aggressiveness. However, how cancer cells adapt to hypoxia and communicate with their …

Extracellular vesicles such as exosomes and microvesicles (MVs) are shed by cancer cells,
are detected in the plasma of cancer patients, and promote cancer progression, but the …

Blood vessels deliver oxygen and nutrients that sustain tumor growth and enable the
dissemination of cancer cells to distant sites and the recruitment of intratumoral immune …