Tumor cell–driven extracellular matrix remodeling drives haptotaxis during metastatic progression
Fibronectin (FN) is a major component of the tumor microenvironment, but its role in
promoting metastasis is incompletely understood. Here, we show that FN gradients elicit …
promoting metastasis is incompletely understood. Here, we show that FN gradients elicit …
Metastasis: tumor cells becoming MENAcing
F Gertler, J Condeelis - Trends in cell biology, 2011 - cell.com
During breast cancer metastasis cells emigrate from the primary tumor to the bloodstream,
and this carries them to distant sites where they infiltrate and sometimes form metastases …
and this carries them to distant sites where they infiltrate and sometimes form metastases …
Autocrine fibronectin inhibits breast cancer metastasis
Both epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET)
are linked to metastasis via their ability to increase invasiveness and enhance tumor …
are linked to metastasis via their ability to increase invasiveness and enhance tumor …
[HTML][HTML] Implications of the hybrid epithelial/mesenchymal phenotype in metastasis
Transitions between epithelial and mesenchymal phenotypes–the epithelial to
mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition …
mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition …
[PDF][PDF] EMT in metastasis: finding the right balance
HC Lo, XHF Zhang - Developmental cell, 2018 - cell.com
The epithelial-to-mesenchymal transition (EMT) is a key driver of cancer metastasis. In this
issue of Developmental Cell, Aiello et al.(2018) demonstrate that an EMT mechanism …
issue of Developmental Cell, Aiello et al.(2018) demonstrate that an EMT mechanism …
Mena invasive (MenaINV) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM
Mena, an actin regulatory protein, functions at the convergence of motility pathways that
drive breast cancer cell invasion and migration in vivo. The tumor microenvironment …
drive breast cancer cell invasion and migration in vivo. The tumor microenvironment …
EMT and MET: necessary or permissive for metastasis?
Epithelial‐to‐mesenchymal transition (EMT) and its reverse mesenchymal‐to‐epithelial
transition (MET) have been suggested to play crucial roles in metastatic dissemination of …
transition (MET) have been suggested to play crucial roles in metastatic dissemination of …
Directed migration of cancer cells guided by the graded texture of the underlying matrix
Living cells and the extracellular matrix (ECM) can exhibit complex interactions that define
key developmental, physiological and pathological processes. Here, we report a new type of …
key developmental, physiological and pathological processes. Here, we report a new type of …
Context-dependent EMT programs in cancer metastasis
Epithelial–mesenchymal transition (EMT) is a developmental process whereby stationary,
adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements …
adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements …
[PDF][PDF] Plasticity between epithelial and mesenchymal states unlinks EMT from metastasis-enhancing stem cell capacity
Forced overexpression and/or downregulation of proteins regulating epithelial-to-
mesenchymal transition (EMT) has been reported to alter metastasis by changing migration …
mesenchymal transition (EMT) has been reported to alter metastasis by changing migration …