NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing
K Shirane, F Miura, T Ito, MC Lorincz - Nature genetics, 2020 - nature.com
De novo DNA methylation (DNAme) in mammalian germ cells is dependent on DNMT3A
and DNMT3L. However, oocytes and spermatozoa show distinct patterns of DNAme. In …
and DNMT3L. However, oocytes and spermatozoa show distinct patterns of DNAme. In …
DNMT3A-dependent DNA methylation is required for spermatogonial stem cells to commit to spermatogenesis
M Dura, A Teissandier, M Armand, J Barau… - Nature …, 2022 - nature.com
DNA methylation plays a critical role in spermatogenesis, as evidenced by the male sterility
of DNA methyltransferase (DNMT) mutant mice. Here, we report a division of labor in the …
of DNA methyltransferase (DNMT) mutant mice. Here, we report a division of labor in the …
KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints
DN Ciccone, H Su, S Hevi, F Gay, H Lei, J Bajko, G Xu… - Nature, 2009 - nature.com
Differential DNA methylation of the paternal and maternal alleles regulates the parental
origin-specific expression of imprinted genes in mammals,. The methylation imprints are …
origin-specific expression of imprinted genes in mammals,. The methylation imprints are …
rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline
Transcriptional silencing by heritable cytosine-5 methylation is an ancient strategy to repress
transposable elements. It was previously thought that mammals possess four DNA …
transposable elements. It was previously thought that mammals possess four DNA …
Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes
S Yano, T Ishiuchi, S Abe, SH Namekawa… - Nature …, 2022 - nature.com
Establishment of the DNA methylation landscape of mammalian oocytes, mediated by the
DNMT3A-DNMT3L complex, is crucial for reproduction and development. In mouse oocytes …
DNMT3A-DNMT3L complex, is crucial for reproduction and development. In mouse oocytes …
Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L
D Bourc'his, TH Bestor - Nature, 2004 - nature.com
Mammalian genomes employ heritable cytosine methylation in the long-term silencing of
retrotransposons and genes subject to genomic imprinting and X chromosome inactivation …
retrotransposons and genes subject to genomic imprinting and X chromosome inactivation …
Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse
DNA methylation is an important epigenetic modification regulating various biological
phenomena, including genomic imprinting and transposon silencing. It is known that …
phenomena, including genomic imprinting and transposon silencing. It is known that …
Role of Tet1 in erasure of genomic imprinting
Genomic imprinting is an allele-specific gene expression system that is important for
mammalian development and function. The molecular basis of genomic imprinting is allele …
mammalian development and function. The molecular basis of genomic imprinting is allele …
Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L
S La Salle, CC Oakes, OR Neaga, D Bourc'his… - BMC developmental …, 2007 - Springer
Background Formation of haploid spermatozoa capable of fertilization requires proper
programming of epigenetic information. Exactly how DNMT3L (DNA methyltransferase 3 …
programming of epigenetic information. Exactly how DNMT3L (DNA methyltransferase 3 …
Intragenic DNA methylation prevents spurious transcription initiation
In mammals, DNA methylation occurs mainly at CpG dinucleotides. Methylation of the
promoter suppresses gene expression, but the functional role of gene-body DNA …
promoter suppresses gene expression, but the functional role of gene-body DNA …