The complement system, while being an essential and very efficient effector component of
innate immunity, may cause damage to the host and result in various inflammatory …

The role of the complement factor H‐related (FHR) proteins in homeostasis, pathogen
defense, and autoimmune disease has recently attracted considerable interest. We highlight …

Complement is a major defense system of innate immunity and aimed to destroy microbes.
One of the central complement regulators is factor H, which belongs to a protein family that …

The factor H (FH) protein family is emerging as a complex network of proteins controlling the
fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range …

Factor H is an essential regulatory protein that plays a critical role in the homeostasis of the
complement system in plasma and in the protection of bystander host cells and tissues from …

The alternative pathway is a continuously active surveillance arm of the complement system,
and it can also enhance complement activation initiated by the classical and the lectin …

For decades immunological research has relied, with variable success, on mouse models to
investigate diseases and possible therapeutic interventions. With the approval of the first …

Inflammation is a common denominator of diseases. The complement system, an intrinsic
part of the innate immune system, is a key driver of inflammation in numerous disorders …

Complement is an essential part of innate immunity as it participates in host defense against
infections, disposal of cellular debris and apoptotic cells, inflammatory processes and …

The complement factor H-related (FHR) proteins are hypothesized to fine-tune the regulatory
role of complement factor H (FH) in the alternative pathway of the complement system …