In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1 (4-11), mammalian tachykinin peptides, on the modulation of pain in mice
CY Fu, YL Zhao, L Dong, Q Chen, JM Ni… - Brain, Behavior, and …, 2008 - Elsevier
Human hemokinin-1 (h HK-1) and its truncated form h HK-1 (4-11) are mammalian
tachykinin peptides encoded by the recently identified TAC4 gene in human, and the …
tachykinin peptides encoded by the recently identified TAC4 gene in human, and the …
Effects and mechanisms of supraspinal administration of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on nociception in mice
Rat/mouse hemokinin 1 (r/m HK-1) is a novel tachykinin peptide whose biological functions
are not fully understood. This work was designed to observe the effects of r/m HK-1 in pain …
are not fully understood. This work was designed to observe the effects of r/m HK-1 in pain …
Rat/mouse hemokinin-1, a mammalian tachykinin peptide, markedly potentiates the antinociceptive effects of morphine administered at the peripheral and supraspinal …
CY Fu, Q Yang, KR Wang, ZQ Kong, Q Chen… - Behavioural brain …, 2006 - Elsevier
Rat/mouse hemokinin 1 (r/m HK-1) is a mammalian tachykinin peptide whose biological
functions are not fully understood. Our recent report showed that icv administration of r/m HK …
functions are not fully understood. Our recent report showed that icv administration of r/m HK …
Characterization of intrathecally administered hemokinin-1-induced nociceptive behaviors in mice
C Watanabe, H Mizoguchi, A Yonezawa, S Sakurada - Peptides, 2010 - Elsevier
Hemokinin-1 is a novel mammalian tachykinin cloned from mouse bone marrow. At present,
pharmacological profile and physiological role of hemokinin-1 are still unclear. In the …
pharmacological profile and physiological role of hemokinin-1 are still unclear. In the …
Centrally administered hemokinin-1 (HK-1), a neurokinin NK1 receptor agonist, produces substance P-like behavioral effects in mice and gerbils
RA Duffy, JA Hedrick, G Randolph, CA Morgan… - …, 2003 - Elsevier
Hemokinin-1 (HK-1) is a recently described mouse tachykinin peptide whose biological
functions are not fully understood. To date, a unique receptor for HK-1 has not been …
functions are not fully understood. To date, a unique receptor for HK-1 has not been …
Role of hemokinin-1 in health and disease
É Borbély, Z Helyes - Neuropeptides, 2017 - Elsevier
Abstract Hemokinin-1 (HK-1), the newest tachykinin encoded by the Tac4 gene was
discovered in 2000. Its name differs from that of the other members of this peptide family due …
discovered in 2000. Its name differs from that of the other members of this peptide family due …
Mouse hemokinin-1 decapeptide subjected to a brain-specific post-translational modification
Background/Aim: The tachykinin mouse hemokinin-1, expressed by the mouse Tac4 gene,
produces either analgesia or nociception, interacting with the neurokinin 1 receptor. TAC4 …
produces either analgesia or nociception, interacting with the neurokinin 1 receptor. TAC4 …
Hemokinin-1 (4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice
Our previous studies have shown that an active fragment of human tachykinins (hHK-1 (4-
11)) produced an opioid-independent analgesia after intracerebroventricular (icv) injection …
11)) produced an opioid-independent analgesia after intracerebroventricular (icv) injection …
Hemokinin-1 mediates pruriceptive processing in the rat spinal cord
H Funahashi, R Naono-Nakayama, K Ebihara… - Neuroscience, 2014 - Elsevier
Abstract Hemokinin-1 (HK-1) is a new mammalian tachykinin peptide consisting of the
amino acid sequence similar to substance P (SP). Although the function of SP, a …
amino acid sequence similar to substance P (SP). Although the function of SP, a …
[HTML][HTML] Hemokinin-1 is an important mediator of pain in mouse models of neuropathic and inflammatory mechanisms
Á Hunyady, Z Hajna, T Gubányi, B Scheich… - Brain Research …, 2019 - Elsevier
The Tac4 gene-derived hemokinin-1 (HK-1) is present in pain-related regions and activates
the tachykinin NK1 receptor, but with binding site and signaling pathways different from …
the tachykinin NK1 receptor, but with binding site and signaling pathways different from …
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