The limitations of subgroup analyses are well established—false positives due to multiple
comparisons, false negatives due to inadequate power, and limited ability to inform …

Is a subgroup effect believable? Updating criteria to evaluate the credibility of subgroup
analyses | The BMJ Skip to main content Intended for healthcare professionals Access provided …

Objective To investigate the planning of subgroup analyses in protocols of randomised
controlled trials and the agreement with corresponding full journal publications. Design …

Objective To investigate the credibility of authors' claims of subgroup effects using a
representative sample of recently published randomised controlled trials. Design Systematic …

Clinicians, when trying to apply trial results to patient care, need to individualize patient care
and, potentially, manage patients based on results of subgroup analyses. Apparently …

Subgroup analyses are an im-portant part of the analysis of a comparative clinical trial.
However, they are commonly overinterpreted1-4 and can lead to further research that is …

Background Subgroup analyses are common in randomised controlled trials (RCTs). There
are many easily accessible guidelines on the selection and analysis of subgroups but the …

Abstract Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a
large trial. This is the result of a combination of reduced statistical power, increased variance …

Background It is well recognized that treatment effects may not be homogeneous across the
study population. Subgroup analyses constitute a fundamental step in the assessment of …

Statistics in Medicine — Reporting of Subgroup Analyses in Clinical Trials | New England Journal
of Medicine Skip to main content The New England Journal of Medicine homepage Advanced …