[PDF][PDF] Fecal microbial transplant capsules are safe in hepatic encephalopathy: a phase 1, randomized, placebo‐controlled trial

JS Bajaj, NH Salzman, C Acharya, RK Sterling… - …, 2019 - Wiley Online Library
Hepatic encephalopathy (HE) can cause major morbidity despite standard of care (SOC;
rifaximin/lactulose). Fecal microbial transplant (FMT) enemas postantibiotics are safe, but …

[PDF][PDF] Fecal microbiota transplant improves cognition in hepatic encephalopathy and its effect varies by donor and recipient

PP Bloom, J Donlan, M Torres Soto… - Hepatology …, 2022 - Wiley Online Library
Early data suggest fecal microbiota transplant (FMT) may treat hepatic encephalopathy (HE).
Optimal FMT donor and recipient characteristics are unknown. We assessed the safety and …

Gut microbiota modulation and fecal transplantation: an overview on innovative strategies for hepatic encephalopathy treatment

R Hassouneh, JS Bajaj - Journal of Clinical Medicine, 2021 - mdpi.com
Simple Summary Treatment of advanced liver disease and its complications continue to be a
challenge due to the complexity of this illness. In recent years, the gut microbiome has been …

[PDF][PDF] Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: a randomized clinical trial

JS Bajaj, Z Kassam, A Fagan, EA Gavis, E Liu… - …, 2017 - Wiley Online Library
Recurrent hepatic encephalopathy (HE) is a leading cause of readmission despite standard
of care (SOC) associated with microbial dysbiosis. Fecal microbiota transplantation (FMT) …

Fecal microbiota transplantation in hepatic encephalopathy: a systematic review

M Madsen, N Kimer, F Bendtsen… - Scandinavian Journal of …, 2021 - Taylor & Francis
Hepatic encephalopathy (HE) is a reversible neurocognitive dysfunction that ranges in
severity from subclinical alterations to coma. Patients with chronic liver disease are …

[HTML][HTML] Microbial functional change is linked with clinical outcomes after capsular fecal transplant in cirrhosis

JS Bajaj, N Salzman, C Acharya, H Takei, G Kakiyama… - JCI insight, 2019 - ncbi.nlm.nih.gov
BACKGROUND Hepatic encephalopathy (HE) is associated with poor outcomes. A prior
randomized, pilot trial demonstrated safety after oral capsular fecal microbial transplant …

Fecal microbiota transplantation in the management of hepatic encephalopathy

D Kao, B Roach, H Park, N Hotte, K Madsen, V Bain… - Hepatology, 2016 - journals.lww.com
Discussion To our knowledge, this is the first report of treating HE with FMT. In this case, the
dramatic clinical improvements, both subjectively and objectively, following serial FMT are …

[HTML][HTML] Long-term outcomes after fecal microbiota transplant in cirrhosis

JS Bajaj, A Fagan, EA Gavis, Z Kassam… - …, 2019 - ncbi.nlm.nih.gov
Methods: For rational donor selection, the microbiome profile of HE patients and healthy
controls were assessed. HE patients demonstrated a relative reduction of Lachnospiraceae …

[PDF][PDF] Fecal microbiota transplant in cirrhosis reduces gut microbial antibiotic resistance genes: analysis of two trials

JS Bajaj, A Shamsaddini, A Fagan… - Hepatology …, 2021 - Wiley Online Library
Antibiotic resistance leads to poor outcomes in cirrhosis. Fecal microbiota transplant (FMT)
is associated with reduction in antibiotic resistance gene (ARG) burden in patients without …

[PDF][PDF] Neuroinflammation in murine cirrhosis is dependent on the gut microbiome and is attenuated by fecal transplant

R Liu, JD Kang, RB Sartor, M Sikaroodi, A Fagan… - …, 2020 - Wiley Online Library
Cirrhosis and hepatic encephalopathy (HE) is associated with an altered gut–liver–brain
axis. Fecal microbial transplant (FMT) after antibiotics improves outcomes in HE, but the …