Adenosine accumulation during ischemia and inflammation protects tissues from injury. In
ischemic tissues adenosine accumulates due to inhibition of adenosine kinase, and in …

Adenosine receptors are present on most cells and organs, yet, although the physiological
effects of adenosine were first described over 60 years ago, the potential therapeutic uses of …

The adenosine receptors A 1, A 2A, A 2B, and A 3 are important and ubiquitous mediators of
cellular signaling, which play vital roles in protecting tissues and organs from damage. In …

Adenosine is an endogenous purine nucleoside that, following its release into the
extracellular space, binds to specific adenosine receptors expressed on the cell surface …

Extracellular adenosine is produced in a coordinated manner from cells following cellular
challenge or tissue injury. Once produced, it serves as an autocrine-and paracrine-signaling …

Introduction: The adenosine receptors A1, A2A, A2B and A3 are important and ubiquitous
mediators of cellular signaling that play vital roles in protecting tissues and organs from …

There are four adenosine receptors, A1, A2A, A2B and A3, together forming a defined
subgroup of G protein coupled receptors. They are well conserved and widely expressed …

Adenosine is a purine nucleoside, which is produced primarily through the metabolism of
adenosine triphosphate (ATP), therefore its levels increase during stressful situations when …

Adenosine is a key endogenous molecule that regulates tissue function by activating four G-
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …

The intensity and duration of host responses are determined by protective mechanisms that
control tissue injury by dampening down inflammation. Adenosine generation and …