Histones are ubiquitous in eukaryotes where they assemble into nucleosomes, binding and
wrapping DNA to form chromatin. One process to modify chromatin and regulate DNA …

Histone proteins compact and organize DNA resulting in a dynamic chromatin architecture
impacting DNA accessibility and ultimately gene expression. Eukaryotic chromatin …

Nucleosomes in eukaryotes act as platforms for the dynamic integration of epigenetic
information. Posttranslational modifications are reversibly added or removed and core …

Histones are a principal constituent of chromatin in eukaryotes and fundamental to our
understanding of eukaryotic gene regulation. In archaea, histones are widespread but not …

Exchanging core histones in the nucleosome for paralogous variants can have important
functional ramifications. Many of these variants, and their physiological roles, have been …

Background Histone wrapping of DNA into nucleosomes almost certainly evolved in the
Archaea, and predates Eukaryotes. In Eukaryotes, nucleosome positioning plays a central …

Archaeal histones wrap DNA into complexes, designated archaeal nucleosomes, that
resemble the tetrasome core of a eukaryotic nucleosome. Therefore, all DNA interactions in …

All archaeal histones studied to date have similar lengths, 66 to 69 amino acid residues that
form three α-helices separated by two β-strand loop regions which together constitute a …

Archaea were recognized as the third domain of cellular life, besides Bacteria and Eukarya,
by Carl Woese and George Fox in 1977 (Woese and Fox, 1977). Since then, it has been …

Abstract Background Archaea, together with Bacteria, represent the two main divisions of life
on Earth, with many of the defining characteristics of the more complex eukaryotes tracing …