Sepsis is characterized by organ dysfunction resulting from a dysregulated inflammatory
response triggered by infection, involving multifactorial and intricate molecular mechanisms …

Sepsis is a highly heterogeneous syndrome that is caused by an imbalanced host response
to infection. Despite huge investments, sepsis remains a contemporary threat with significant …

Abstract Background: Hypoxia-inducible factor-1 (HIF-1) is a molecular key player in
response to hypoxemic/inflammatory conditions prevailing in sepsis. In a prospective …

HIF-1 is a ubiquitous signaling molecule constantly expressed by the body, but is degraded
during normoxic conditions. In hypoxic conditions, it persists and is active. Hypoxia is often …

Hypoxia-inducible factors (HIFs) are transcription factors critical for the adaptive response to
hypoxia. There is also an essential link between hypoxia and inflammation, and HIFs have …

How the immune system is negatively affected by sepsis is not fully understood. In this issue
of Immunity, Shalova et al.(2015) show that during human sepsis monocytes upregulate …

Sepsis, the leading cause of death in intensive care units, reflects a detrimental host
response to infection in which bacteria or LPS act as potent activators of immune cells …

Hypoxia inducible factor 1 alpha (HIF-1α) is linked to the metabolic and immune alterations
in septic patients. Stabilization of HIF-1α by hypoxia or inflammation promotes the …

Abstract Introduction Hypoxia-inducible factor-1 (HIF1) controls the expression of genes
involved in the cellular response to hypoxia. No information is available on its expression in …

Hypoxia‐inducible factors (HIFs) have emerged in recent years as critical regulators of
immunity. Localised, low oxygen tension is a hallmark of inflamed and infected tissues …