Objectives: Elderly patients often suffer from cognitive dysfunction following surgery.
However, the mechanisms underlying this phenomenon still remain unclear. This study …

Background Postoperative cognitive dysfunction (POCD) is a very common complication that
might increase the morbidity and mortality of elderly patients after surgery. However, the …

Postoperative cognitive dysfunction (POCD) is a neurological sequela of surgery and
anesthesia. It occurs with high incidence in the aged population. Neuroinflammation is …

Background Postoperative cognitive dysfunction (POCD) is a debilitating neurological
complication in surgical patients. Current research has focused mainly on microglial …

Aim Autophagy is a catabolic process, which plays a pivotal role in neuronal homeostases.
Sirtuin-1 (Sirt1, Silent information regulator family protein 1) is a protein deacetylase that is …

Postoperative cognitive dysfunction (POCD) is a sever postsurgical neurological
complication in the elderly population. As the global acceleration of population ageing …

Traumatic brain injury (TBI) triggers neuronal death mechanisms that significantly induce
neuronal loss and neurological dysfunction. Our previous study revealed that Sirt1 could …

Abstract Background Sirtuin 1 (Sirt1) is a recognized longevity gene and has been shown to
be associated with aging and its related diseases. Hippocampal volume is considered to be …

Background Though the exact mechanisms regarding brain aging and its relation to
neurodegenerative disorders are not precise, oxidative stress, the key regulators of …

Background: Postoperative cognitive dysfunction (POCD) is a common complication after
surgery and anesthesia. In this study, we aimed to determine the neuroprotective …