The G protein coupled receptors (GPCRs) have been considered as one of the largest
families of validated drug targets, which involve in almost overall physiological functions and …

G protein-coupled receptors (GPCRs) are involved in numerous key neurotransmitter
systems in the brain that are disrupted in Alzheimer's disease (AD). GPCRs also directly …

Abstract Alzheimer's disease (AD), the most common cause of age-dependent dementia, is
one of the most significant healthcare problems worldwide. Aggravating this situation, drugs …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the most
common cause of dementia in the elderly. The complexity of AD has hindered the …

Alzheimer's disease (AD) is characterized by the extracellular deposition of the β-amyloid
protein (Aβ). Aβ is a fragment of a much larger precursor protein, the amyloid precursor …

β-Site APP-cleaving enzyme (BACE) is a membrane-bound aspartyl protease involved in
the production of Alzheimer's disease (AD) Aβ amyloid peptides. This enzyme is …

Alzheimer's disease (AD) is an intractable, neurodegenerative disease that appears to be
brought about by both genetic and non-genetic factors. The neuropathology associated with …

The β‐site amyloid precursor protein cleaving enzyme‐1 (BACE 1), an essential protease for
the generation of amyloid‐β (Aβ) peptide, is a major drug target for Alzheimer's disease …

The diagnosis of Alzheimer's disease (AD) relies principally on clinical criteria for probable
and possible AD as defined by the NINCDS-ADRDRA. The field is desperately lacking of …

Over the past two decades, many studies have identified significant contributions of toxic β-
amyloid peptides (Aβ) to the etiology of Alzheimer's disease (AD), which is the most common …