The paradigm for the response to hypoxia is erythropoietin gene expression; activation of
hypoxia-inducible factor-1 (HIF-1) results in erythropoietin production. Previously, we found …

Transcriptional regulation of gene expression by hypoxia is an important, but yet only
marginally characterized mechanism by which organisms adapt to low oxygen …

Hypoxia-inducible factor 1 (HIF-1) activates erythropoietin gene transcription in Hep3B cells
subjected to hypoxia. HIF-1 activity is also induced by hypoxia in non-erythropoietin …

SUMMARY 1 The mechanisms controlling the expression of the gene encoding for the
hormone erythropoietin (EPO) are exemplary for oxygen‐regulated gene expression. In …

Erythropoietin gene (EPO) expression is activated by tissue hypoxia in renal peritubular
interstitial fibroblasts and, to a lesser extent, in hepatocytes and Ito cells of the liver. A …

Erythropoietin (EPO) gene transcription is activated in kidney cells in vivo and in Hep3B
cells exposed to hypoxia or cobalt chloride. Hypoxia-inducible factor 1 (HIF-1) is a nuclear …

Transcription of the human erythropoietin (EPO) gene is activated in Hep3B cells exposed to
hypoxia. Hypoxia-inducible factor 1 (HIF-1) is a nuclear factor whose DNA binding activity is …

Hypoxia‐inducible factor 1 α (HIF1α) and its related factor, HLF, activate expression of a
group of genes such as erythropoietin in response to low oxygen. Transfection analysis …

The ability to adapt successfully to periods of relative hypoxia is crucial to the survival of all
higher life forms. Several genes have previously been identified which are up-regulated in …

Hypoxia-inducible factor 1 (HIF-1) is a DNA-binding protein that activates erythropoietin
(Epo) gene transcription in Hep3B cells subjected to hypoxia or cobalt chloride treatment …