Triphenylphosphine gold (I) derivatives promote antiviral effects against the Chikungunya virus

RL Aires, IA Santos, JV Fontes, FRG Bergamini… - Metallomics, 2022 - academic.oup.com
Herein a systematic series of four [AuLL'] n+ n= 0,+ 1 complexes, where L= 1, 3-bis (mesityl)
imidazole-2-ylidene (IMes), or triphenylphosphine (PPh3), and L'= chloride, or 4 …

[HTML][HTML] Organometallic complex strongly impairs chikungunya virus entry to the host cells

DM Oliveira, IA Santos, DOS Martins… - Frontiers in …, 2020 - frontiersin.org
Chikungunya fever is a disease caused by the Chikungunya virus (CHIKV) that is
transmitted by the bite of the female of Aedes sp. mosquito. The symptoms include fever …

[HTML][HTML] Heteroleptic (S^ C)-cyclometallated gold (III) complexes as novel antiviral agents

M Balsera-Manzanero, RG Soengas… - Heliyon, 2024 - cell.com
Despite the increasingly widespread clinical impact of adenovirus (HAdV) infections in
healthy individuals and the associated high morbidity in immunosuppressed patients …

[HTML][HTML] Insights into the role of the cobalt (III)-thiosemicarbazone complex as a potential inhibitor of the Chikungunya virus nsP4

DOS Martins, RAC Souza, MCLC Freire… - JBIC Journal of …, 2023 - Springer
Chikungunya virus (CHIKV) is the causative agent of chikungunya fever, a disease that can
result in disability. Until now, there is no antiviral treatment against CHIKV, demonstrating …

[HTML][HTML] Inhibition of chikungunya virus by picolinate that targets viral capsid protein

R Sharma, B Fatma, A Saha, S Bajpai, S Sistla… - Virology, 2016 - Elsevier
The protein-protein interactions (PPIs) of the transmembrane glycoprotein E2 with the
hydrophobic pocket on the surface of capsid protein (CP) plays a critical role in alphavirus …

[HTML][HTML] Fragmentation study, dual anti-bactericidal and anti-viral effects and molecular docking of cobalt (III) complexes

LP Fernandes, JMB Silva, DOS Martins… - International journal of …, 2020 - mdpi.com
Considering our previous findings on the remarkable activity exhibited by cobalt (III) with 2-
acetylpyridine-N (4)-R-thiosemicarbazone (Hatc-R) compounds against Mycobacterium …

[HTML][HTML] Repurposing potential of rimantadine hydrochloride and development of a promising platinum (II)-rimantadine metallodrug for the treatment of Chikungunya …

IA Santos, AK dos Santos Pereira, M Guevara-Vega… - Acta Tropica, 2022 - Elsevier
Most of the patients infected with Chikungunya virus (CHIKV) develop chronic
manifestations characterized by pain and deformity in joints, impacting their quality of life …

Design, synthesis, antiviral evaluation, and In silico studies of acrylamides targeting nsP2 from Chikungunya virus

BG de Souza, S Choudhary, GG Vilela… - European Journal of …, 2023 - Elsevier
The Togaviridae family comprises several New-and Old-World Alphaviruses that have been
responsible for thousands of human illnesses, including the RNA arbovirus Chikungunya …

Development of new drug candidate for the inhibition of Nipah virus phosphoprotein by Quercetin Derivatives through in silico drug design approaches

A Berkane, N Kundu, AA Munia, B Chakrabarty… - Journal of the Indian …, 2024 - Elsevier
Abstract The Nipah virus (NiV) is a pathogenic infection that can cause a pandemic, hence
presenting a substantial risk to both human and animal communities. Despite its virulence …

Metal ion complexes of antivirally active nucleotide analogues. Conclusions regarding their biological action

H Sigel - Chemical Society Reviews, 2004 - pubs.rsc.org
Acyclic nucleoside phosphonates (ANPs), ie, analogues of (2′-deoxy) nucleoside 5′-
monophosphates, have been studied during the past 15 years for their potential as antiviral …