The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues,
and organs. Under extended exposure to reduced oxygen levels, cells are able to survive …

Angiogenesis is a key enabling feature of mammalian embryonic development and tumor
progression, which provides oxygen and nutrients that are required for vessel growth and …

Hypoxia is a state where oxygen availability/delivery is below the level necessary to
maintain physiological oxygen tension for a particular tissue. It is well-established that when …

Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in
ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified …

Abstract Hypoxia-Inducible Factor (HIF)-1 is a dimeric protein complex that plays an integral
role in the body's response to low oxygen concentrations, or hypoxia. HIF-1 is among the …

The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism.
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular …

Hypoxia-inducible factors (HIF) are transcription factors responding to reduced oxygen
levels and are of utmost importance for regulation of a widespread of cellular processes, eg …

The formation of new blood vessels, angiogenesis, is an essential process during
development and disease. Angiogenesis is well known as a crucial step in tumor growth and …

Abstract Hypoxia-inducible factor-1 (HIF-1), composed of HIF-α and HIF-β subunits, is a
heterodimeric transcriptional activator. In response to hypoxia, stimulation of growth factors …

Atherosclerosis is a highly prevalent disease that can significantly increase the risk of major
vascular events, such as myocardial or cerebral infarctions. The anoxemia theory states that …