The influence of radiation sterilisation on some β-blockers in the solid state

B Marciniec, M Ogrodowczyk, B Czajka, M Hofman - Thermochimica acta, 2011 - Elsevier
Six derivatives of aryloxyalkylaminopropanol of known β-adrenolytic activity (acebutolol,
alprenolol, atenolol, metoprolol, pindolol, propranolol) in solid phase were exposed to the …

Identification of radiodegradation products of acebutolol and alprenolol by HPLC/MS/MS

M Ogrodowczyk, K Dettlaff, P Kachlicki… - Journal of AOAC …, 2015 - academic.oup.com
Two therapeutically active compounds from the group of β-blockers, acebutolol (AC) and
alprenolol (AL), in solid form were subjected to ionizing radiation emitted by a beam of high …

[HTML][HTML] Radiodegradation of nadolol in the solid state and identification of its radiolysis products by UHPLC–MS method

M Ogrodowczyk, K Dettlaff, W Bednarski, B Ćwiertnia… - Chemical Papers, 2018 - Springer
Abstract Nadolol ((2 R*, 3 S*)-5-{[(2 R*)-3-(tert-butylamino)-2-hydroxypropyl] oxy}-1, 2, 3, 4
tetrahydronaphthalene-2, 3-diol) in substantia was exposed to ionizing radiation generated …

Spectroscopic analysis of pindolol irradiated in the solid state

M Ogrodowczyk, B Marciniec, P Kachlicki - Open Chemistry, 2014 - degruyter.com
Abstract Pindolol ((2RS)-(1-(1H-indol-4-iloxy)-3-[(1-metyloetylo) amino]-2-propanol) in
substantia was exposed to ionising radiation emitted by high energy electrons from an …

HPLC detection and quantification of radiolytic products of eight β-blockers irradiated in the solid state and hypotheses on their origins

A Engalytcheff, JP Vanhelleputte, B Tilquin - Pharmaceutical research, 2004 - Springer
Purpose. The radiolytic products of eight β-blockers were studied in order to understand the
mechanisms of irradiation of drugs in the solid state. Methods. The drugs were analyzed by …

γ-Promotion of thermal stability and radiolysis mechanism of atenolol β-blocker

MM Abou-Sekkina, MA El-Reis, FA Aly, AA Wassel - Thermochimica acta, 2002 - Elsevier
Atenolol (At) β-blocker antihypertensive active ingredient has been investigated for its X-ray
diffraction analysis, thermogravimetric analysis (TGA), differential thermal analysis (DTA), IR …

Effect of radiation sterilization on alprenolol in the solid state studied by high-performance thin-layer chromatography

B Marciniec, M Ogrodowczyk… - Journal of AOAC …, 2010 - academic.oup.com
The possibility of radiation sterilization of alprenolol (AL) has been studied. Irradiation of AL
in solid form with a 25 kGy beam of electrons caused only an insignificant change in color …

Thermal behavior of the β-blocker propranolol

B Ambrozini, P Cervini, ETG Cavalheiro - Journal of Thermal Analysis and …, 2016 - Springer
The thermal behavior of the β-blocker anti-hypertensive drug propranolol was investigated
using thermoanalytical techniques TG–DTA, DSC and the evolved gas analysis by TG–FTIR …

[HTML][HTML] Electron Beam Radiation as a Safe Method for the Sterilization of Aceclofenac and Diclofenac—The Usefulness of EPR and 1H-NMR Methods in …

M Janiaczyk, A Jelińska, A Woźniak-Braszak, P Bilski… - Pharmaceutics, 2022 - mdpi.com
Diclofenac (DC)[2-(2, 6-Dichloroanilino) phenyl] acetic acid,) and aceclofenac (AC) 2-[2-[2-
[(2, 6-dichlorophenyl) amino] phenyl] acetyl] oxyacetic acid in substantia were subjected to …

Thermal analysis and crystallization from melts: β-adrenergic compounds

J Canotilho, R Castro, M Rosado, S Nunes… - Journal of thermal …, 2010 - akjournals.com
The growth of atenolol, pindolol and betaxolol hydrochloride from melt was investigated by
differential scanning calorimetry (DSC) and polarized light thermal microscopy (PLTM) …