There is growing evidence that reduced neurotrophic support is a significant factor in the
pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's …

The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons, and have since been shown to control a …

Neurotrophins provide trophic and tropic support for different neuronal subpopulations in the
developing and adult nervous systems. Expression of the neurotrophins and their receptors …

Cytokines are a heterogenous group of polypeptide mediators that have been associated
with activation of numerous functions, including the immune system and inflammatory …

It is beyond doubt that the neurotrophin family of proteins plays key roles in determining the
fate of the neuron, not only during embryonic development, but also in the adult brain …

Nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5
are members of a family of proteins (the neurotrophins) that promote the differentiation …

Neurotrophins have diverse functions in the CNS. Initially synthesized as precursors
(proneurotrophins), they are cleaved to produce mature proteins, which promote neuronal …

▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons and have since been shown to control a …

Neurodegenerative disorders are prevalent, complex and devastating conditions, with very
limited treatment options currently available. While they manifest in many forms, there are …