Infantile spasms present a constellation of symptoms and laboratory findings that suggest a
role of subcortical circuits in the pathogenesis of this illness. The clinical features of spasms …

Infantile spasms is a severe epileptic encephalopathy of infancy. The fundamental cause is
unknown, although a number of predisposing conditions are recognized. In this article, the …

Infantile spasms (IS) are so typically associated with West syndrome that the term IS,
properly referred to as a seizure type, is currently used synonymously with this severe …

Infantile spasms constitute an age-dependent epilepsy, highly associated with cognitive
impairment, autism, and movement disorders. Previous classification systems focused on a …

Recent observations have contributed significantly to our understanding of the
pathophysiology of infantile spasms, and have allowed a number of hypotheses to be …

While infantile spasms is the most common catastrophic epilepsy of infancy and early-
childhood, very little is known about the basic mechanisms responsible for this devastating …

Infantile spasms is an epilepsy syndrome with several distinctive features, including age
specificity during infancy, characteristic semiology (epileptic spasms), specific …

Whether the cerebral or subcortical lesions are involved in the pathogenesis in infantile
spasms (IS) remains to be determined. To investigate the functional lesions of the …

Infantile spasms begin in a very active phase of brain development. The new
neuropathological techniques have shed light on changes in the fine structure of brain in …

The cerebral cortex and thalamus can both generate cyclical oscillations of neuronal activity.
Within the thalamus, sleep spindles are generated as a recurrent interaction between …