RAF-MEK-ERK pathway in cancer evolution and treatment
Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
Targeting aberrant RAS/RAF/MEK/ERK signaling for cancer therapy
U Degirmenci, M Wang, J Hu - Cells, 2020 - mdpi.com
The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter-and intra-
cellular communication, which regulates fundamental cell functions such as growth, survival …
cellular communication, which regulates fundamental cell functions such as growth, survival …
[HTML][HTML] “RAF” neighborhood: Protein–protein interaction in the Raf/Mek/Erk pathway
B Cseh, E Doma, M Baccarini - FEBS letters, 2014 - Elsevier
Abstract The Raf/Mek/Erk signaling pathway, activated downstream of Ras primarily to
promote proliferation, represents the best studied of the evolutionary conserved MAPK …
promote proliferation, represents the best studied of the evolutionary conserved MAPK …
The MEK/ERK network as a therapeutic target in human cancer
R Barbosa, LA Acevedo, R Marmorstein - Molecular Cancer Research, 2021 - AACR
Abstract The RAS–RAF–MEK–ERK pathway is the most well-studied of the MAPK cascades
and is critical for cell proliferation, differentiation, and survival. Abnormalities in regulation …
and is critical for cell proliferation, differentiation, and survival. Abnormalities in regulation …
Raf family kinases: old dogs have learned new tricks
D Matallanas, M Birtwistle, D Romano… - Genes & …, 2011 - journals.sagepub.com
First identified in the early 1980s as retroviral oncogenes, the Raf proteins have been the
objects of intense research. The discoveries 10 years later that the Raf family members (Raf …
objects of intense research. The discoveries 10 years later that the Raf family members (Raf …
Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK pathway
KK Wong - Recent patents on anti-cancer drug discovery, 2009 - ingentaconnect.com
The Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) pathway mediates cellular
responses to different growth signals and is frequently deregulated in cancer. There are …
responses to different growth signals and is frequently deregulated in cancer. There are …
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
PJ Roberts, CJ Der - Oncogene, 2007 - nature.com
Mitogen-activated protein kinase (MAPK) cascades are key signaling pathways involved in
the regulation of normal cell proliferation, survival and differentiation. Aberrant regulation of …
the regulation of normal cell proliferation, survival and differentiation. Aberrant regulation of …
Targeting oncogenic Raf protein-serine/threonine kinases in human cancers
R Roskoski Jr - Pharmacological Research, 2018 - Elsevier
Abstract The Ras-Raf-MEK-ERK signal transduction cascade is arguably the most important
oncogenic pathway in human cancers. Ras-GTP promotes the formation of active …
oncogenic pathway in human cancers. Ras-GTP promotes the formation of active …
ERK and beyond: insights from B-Raf and Raf-1 conditional knockouts
G Galabova-Kovacs, A Kolbus, D Matzen, K Meiss… - Cell cycle, 2006 - Taylor & Francis
The Raf/MEK/ERK cascade is a highly conserved signal transduction module whose
activation reportedly results in a plethora of physiological outcomes. Depending on the cell …
activation reportedly results in a plethora of physiological outcomes. Depending on the cell …
Conferring specificity on the ubiquitous Raf/MEK signalling pathway
E O'neill, W Kolch - British journal of cancer, 2004 - nature.com
Abstract The Raf-MEK-ERK signalling pathway controls fundamental cellular processes
including proliferation, differentiation and survival. It remains enigmatic how this pathway …
including proliferation, differentiation and survival. It remains enigmatic how this pathway …