Most metastatic cancers are incurable—a fact that underscores the limitations of our existing
paradigms for understanding metastasis. In this Review, we use breast cancer to explore …

Tumour metastasis is a dynamic and systemic process. It is no longer seen as a tumour cell-
autonomous program but as a multifaceted and complex series of events, which is …

Metastatic disease is the culmination of cancer and its most common life-threatening
manifestation. The highly complex process by which cancer cells disseminate to and …

Multiple factors act in concert to define the fate of disseminated tumor cells (DTC) to enter
dormancy or develop overt metastases. Here, we review these factors in the context of three …

Despite many years of basic and clinical research aimed at curbing tumour growth,
metastasis remains the prime reason why cancer patients succumb to their disease …

Tumours are heterogeneous populations composed of different cells types: stem cells with
the capacity for self-renewal and more differentiated cells lacking such ability. The overall …

Breast cancer remains a leading cause of morbidity and mortality in women, mainly due to
the propensity of primary breast tumors to metastasize to regional and distant sites …

Metastases are responsible for the vast majority of cancer-related deaths, but, despite
intense efforts to understand their underlying mechanisms with the goal of uncovering …

Metastases account for the great majority of cancer-associated deaths, yet this complex
process remains the least understood aspect of cancer biology. As the body of research …

Metastasis can occur many years after primary tumour treatment. However, the status of the
tumour during this period of dormancy is poorly understood. As part of our ongoing …