Neuropharmacology in traumatic brain injury: from preclinical to clinical neuroprotection?

D Lerouet, C Marchand‐Leroux… - Fundamental & clinical …, 2021 - Wiley Online Library
Traumatic brain injury (TBI) constitutes a major health problem worldwide and is a leading
cause of death and disability in individuals, contributing to devastating socioeconomic …

Targets of neuroprotection and review of pharmacological interventions in traumatic brain injury

MI Hiskens - Journal of Pharmacology and Experimental …, 2022 - ASPET
Traumatic brain injury (TBI) is a major contributor to disability and death worldwide, and
manifests in cognitive, behavioral, and motor impairment. Although there have been …

Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies

DJ Loane, AI Faden - Trends in pharmacological sciences, 2010 - cell.com
Traumatic brain injury (TBI) causes secondary biochemical changes that contribute to
subsequent tissue damage and associated neuronal cell death. Neuroprotective treatments …

Neuroprotection for traumatic brain injury

DJ Loane, BA Stoica, AI Faden - Handbook of clinical neurology, 2015 - Elsevier
Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Despite
extensive preclinical research supporting the effectiveness of neuroprotective therapies for …

Exploring new routes for neuroprotective drug development in traumatic brain injury

T Janowitz, DK Menon - Science translational medicine, 2010 - science.org
Worldwide, traumatic brain injury (TBI) is a major cause of mortality and morbidity with a
substantial predicted increase in incidence. Despite an obvious need, there are no …

Evaluation of pharmacological treatment strategies in traumatic brain injury

N Marklund, A Bakshi, DJ Castelbuono… - Current …, 2006 - ingentaconnect.com
Traumatic brain injury (TBI) is a devastating disease, predominantely affecting young
people. Although the prognosis for TBI victims has improved in recent years, many survivors …

Emerging treatments for traumatic brain injury

Y Xiong, A Mahmood, M Chopp - Expert opinion on emerging drugs, 2009 - Taylor & Francis
Background: This review summarizes promising approaches for the treatment of traumatic
brain injury (TBI) that are in either preclinical or clinical trials. Objective: The …

Neuroprotective agents in traumatic brain injury

AIR Maas - Expert opinion on investigational drugs, 2001 - Taylor & Francis
The role of neuroprotection in traumatic brain injury (TBI) is reviewed. Basic research and
experimental investigations have identified many different compounds with potential …

Neuroprotection in traumatic brain injury: a complex struggle against the biology of nature

JW Schouten - Current opinion in critical care, 2007 - journals.lww.com
Traumatic brain injury is a complex disease, and development of clinically effective
neuroprotective agents is a difficult task. Experimental traumatic brain injury has provided …

[HTML][HTML] Neuroprotective strategies for traumatic brain injury: improving clinical translation

SV Kabadi, AI Faden - International journal of molecular sciences, 2014 - mdpi.com
Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to
delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating …