Aging is associated with an increased risk of frailty, disability, and mortality. Strategies to
delay the degenerative changes associated with aging and frailty are particularly interesting …

Senescent cells accumulate in fat with aging. We previously found genetic clearance of
senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy. Here we show that …

Tissue-resident stem cell senescence leads to stem cell exhaustion, which is a major cause
of physiological and pathological ageing. Stem cell-derived extracellular vesicles (SC-EVs) …

Aging drives progressive loss of the ability of tissues to recover from stress, partly through
loss of somatic stem cell function and increased senescent burden. We demonstrate that …

Aging is a degenerative process that leads to tissue dysfunction and death. Embryonic stem
cells (ESCs) have great therapeutic potential for age-related diseases due to their capacity …

Aging is a process of cellular and tissue dysfunction characterized by different hallmarks,
including cellular senescence. However, there is proof that certain features of aging and …

Aging is associated with high prevalence of chronic degenerative diseases that take a large
part of the increasing burden of morbidities in a growing demographic of elderly people …

Background Human adipose tissue is an ideal autologous source of mesenchymal stem
cells (MSCs) for various regenerative medicine and tissue engineering strategies. Aged …

Tissues undergo a process of degeneration as the body ages. Mesenchymal stem cells
(MSCs) have been found to have major potential in delaying the aging process in tissues …

Background Adipose-derived mesenchymal stem cells (ADMSCs) have attracted
widespread interest as cell-based tissue repair systems. To obtain adequate quantities of …