Natural killer cells in myeloid malignancies: immune surveillance, NK cell dysfunction, and pharmacological opportunities to bolster the endogenous NK cells

M Carlsten, M Järås - Frontiers in immunology, 2019 - frontiersin.org
Natural killer (NK) cells are large granular lymphocytes involved in our defense against
certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti …

Natural killer cells: a review of biology, therapeutic potential and challenges in treatment of solid tumors

K Choucair, JR Duff, CS Cassidy, MT Albrethsen… - Future …, 2019 - Taylor & Francis
Natural killer (NK) cells lead immune surveillance against cancer and early elimination of
small tumors. Owing to their ability to engage tumor targets without the need of specific …

NK cells in the treatment of hematological malignancies

AP Gonzalez-Rodriguez, M Villa-Álvarez… - Journal of clinical …, 2019 - mdpi.com
Natural killer (NK) cells have the innate ability to kill cancer cells, however, tumor cells may
acquire the capability of evading the immune response, thereby leading to malignancies …

Natural killer cells: diverse functions in tumor immunity and defects in pre-neoplastic and neoplastic stages of tumorigenesis

A Jewett, J Kos, K Kaur, T Safaei, C Sutanto… - Molecular Therapy …, 2020 - cell.com
Natural killer (NK) cells are the key immune effectors with the ability to mediate selection and
differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and …

Natural killer cells: a promising immunotherapy for cancer

J Chu, F Gao, M Yan, S Zhao, Z Yan, B Shi… - Journal of translational …, 2022 - Springer
As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have
recently gained attention as an important type of innate immune regulatory cell. NK cells can …

Roles of natural killer cells in immunity to cancer, and applications to immunotherapy

NK Wolf, DU Kissiov, DH Raulet - Nature Reviews Immunology, 2023 - nature.com
Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

Targeting natural killer cells in solid tumors

G Habif, A Crinier, P André, E Vivier… - Cellular & molecular …, 2019 - nature.com
Natural killer (NK) cells are innate lymphoid cells endowed with cytolytic activity and a
capacity to secrete cytokines and chemokines. Several lines of evidence suggest that NK …

Natural killer cells: the linchpin for successful cancer immunotherapy

KA Shaver, TJ Croom-Perez, AJ Copik - Frontiers in immunology, 2021 - frontiersin.org
Cancer immunotherapy is a highly successful and rapidly evolving treatment modality that
works by augmenting the body's own immune system. While various immune stimulation …

Human natural killer cell development and biology

SS Farag, MA Caligiuri - Blood reviews, 2006 - Elsevier
Natural killer cells are important innate immune effector cells with potentially broad
applications in the treatment of human malignancy due to their ability to lyse neoplastic cells …

Natural killer cell-based therapies targeting cancer: possible strategies to gain and sustain anti-tumor activity

CIM Dahlberg, D Sarhan, M Chrobok, AD Duru… - Frontiers in …, 2015 - frontiersin.org
Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill
tumor cells without the requirement of prior antigen exposure. Since then, NK cells have …