Neurodegenerative disorders are characterized by the presence of inflammation in areas
with neuronal cell death and a regional increase in iron that exceeds what occurs during …

Iron is a vital element required by almost all cells for their normal functioning. The well-
established role of iron in oxidative metabolism, myelination and synthesis of …

Iron (Fe) is an essential element for many metabolic processes, serving as a cofactor for
heme and nonheme proteins. Cellular iron deficiency arrests cell growth and leads to cell …

Astrocytes play a crucial role in proper iron handling within the central nervous system. This
competence can be fundamental, particularly during neuroinflammation, and …

Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Iron accumulation or iron overload in brain is commonly associated with neurodegenerative
disorders such as Parkinson's and Alzheimer's diseases, and also plays a role in cellular …

Disturbance of the brain homeostasis, either directly via the formation of abnormal proteins
or cerebral hypo-perfusion, or indirectly via peripheral inflammation, will activate microglia to …

Iron is an essential trace element required for important brain functions including oxidative
metabolism, synaptic plasticity, myelination, and the synthesis of neurotransmitters …

The brain shares with other organs the need for a constant and readily available supply of
iron and has a similar array of proteins available to it for iron transport, storage, and …

The present article reviews the roles and interactions of iron and neuroinflammation in
Alzheimer's disease. It highlights the importance of neuroinflammatory changes in the glial …