Molecular pathogenesis and systemic therapies for hepatocellular carcinoma

JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …

The therapeutic landscape of hepatocellular carcinoma

S Gallage, M García-Beccaria, M Szydlowska… - Med, 2021 - cell.com
The liver is endowed with an amazing regenerative capacity that allows it to withstand an
enormous amount of damage. Nevertheless, it is precisely this highly regenerative capacity …

Targeted therapy for hepatocellular carcinoma: Challenges and opportunities

S Chen, Q Cao, W Wen, H Wang - Cancer letters, 2019 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, which
ranks as the sixth of cancer-related death. Despite the emergence of targeted therapy …

Recent developments and therapeutic strategies against hepatocellular carcinoma

M Yarchoan, P Agarwal, A Villanueva, S Rao… - Cancer research, 2019 - AACR
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer deaths globally.
The landscape of systemic therapy has recently changed, with six additional systemic …

Molecular therapies and precision medicine for hepatocellular carcinoma

JM Llovet, R Montal, D Sia, RS Finn - Nature reviews Clinical oncology, 2018 - nature.com
The global burden of hepatocellular carcinoma (HCC) is increasing and might soon surpass
an annual incidence of 1 million cases. Genomic studies have established the landscape of …

Evolution of systemic therapy for hepatocellular carcinoma

RS Finn, AX Zhu - Hepatology, 2021 - Wiley Online Library
Despite being one of the leading causes of cancer death globally, hepatocellular carcinoma
(HCC) has historically not been the focus of novel drug development. That has changed in …

Hepatocellular carcinoma: old friends and new tricks

E Kim, P Viatour - Experimental & molecular medicine, 2020 - nature.com
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer and a leading
cause of cancer-related deaths worldwide. Ninety percent of HCC cases arise from cirrhosis …

Hepatocellular carcinoma: molecular mechanisms and targeted therapies

A Alqahtani, Z Khan, A Alloghbi, T S. Said Ahmed… - Medicina, 2019 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumors
worldwide. HCC is a complex process that is associated with several etiological factors …

From molecular biology to targeted therapies for hepatocellular carcinoma: the future is now

RWC Pang, RTP Poon - Oncology, 2007 - karger.com
Hepatocellular carcinoma (HCC) is characterized as a highly chemoresistant cancer with no
effective systemic therapy. Despite surgical or locoregional therapies, prognosis remains …

Targeted therapy and personalized medicine in hepatocellular carcinoma: drug resistance, mechanisms, and treatment strategies

D Galun, T Srdic-Rajic, A Bogdanovic… - Journal of …, 2017 - Taylor & Francis
Hepatocellular carcinoma (HCC) is characterized by a growing number of new cases
diagnosed each year that is nearly equal to the number of deaths from this cancer. In a …